国际皮肤性病学杂志    2007 33 (5): 296-298   ISSN: 2096-5540  CN: 32-1880/R   调节性T细胞与天疱疮 申洁, 陈向东, 刘健航 上海交通大学医学院附属第九人民医院皮肤科 200011 收稿日期 2007-01-15  修回日期 null  网络版发布日期 null 参考文献  [1] Tomasello E,Blery M,Vely F,et al.Signaling pathways engaged by NK cell receptors:double concerto for activating receptors,inhibitory receptors and NK cells.Semin Immunol,2000,12(2):139-147. [2] Ravetch JV,Lanier LL.Immune inhibitory receptors.Science,2000,290 (5489):84-89. [3] Malek TR,Yu A,Vincek V,et al.CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice.Implications for the nonredundant function of IL-2.Immunity,2002,17(2):167-178. [4] Boden E,Tang Q,Bour-Jordan H,et al.The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.Novartis Found Symp,2003,252:55-63. [5] Fontenot JD,Gavin MA,Rudensky AY.Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.Nat Immunol,2003,4 (4):330-336. [6] Yamagiwa S,Gray JD,Hashimoto S,et al.A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood.J Immunol,2001,166(12):7282-7289. [7] Groux H.Type I T regulatory cells:their role in the control of immune responses.Transplantation,2003,15:8-12. [8] Lopez-Robles E,Avalos-Diaz E,Vega-Memije E,et al.TNFalpha and IL-6 are mediators in the blistering process of pemphigus.Int J Dermatol,2001,40 (3):185-188. [9] Caproni M,Giomi B,Cardinali C,et al.Further support for a role for Th2-like cytokines in blister formation ofpemphigua.Clin Immunol,2001,98 (2):264-271. [10] Toto P,Feliciani C,Amerio P,et al.Immune modulation in pemphigus vulgaris:role of CD28 and IL-10.J Immunol,2000,164 (1):522-529. [11] Marra LE,Zhang ZX,Joe B,et al.IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha.J Immunol,2004,172 (2):1028-1035. [12] Veldman C,Hohne A,Dieckmann D,et al.Type Ⅰ regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris.J Immunol,2004,172 (10):6468-6475. [13] Hertl M,Eming R,Veldman C.T cell control in autoimmune bullous skin disorders.J Clin Invest,2006,116 (5):1159. 通讯作者: 刘健航,email:liujianhang@medmail.com.cn