国际皮肤性病学杂志    2007 33 (5): 293-295   ISSN: 2096-5540  CN: 32-1880/R   雷公藤内酯醇对细胞凋亡相关信号转导的调控 杨盛波, 文海泉, 张桂英 中南大学湘雅二医院皮肤科 长沙 410011 收稿日期 2006-12-05  修回日期 null  网络版发布日期 null 参考文献  [1] Liu Q,Chen T,Chen H,et al.Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.Biochem Biophys Res Commun,2004,319 (3):980-986. [2] Choi YJ,Kim TG,Kim YH,et al.Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cella.Biochem Pharmacol,2003,66 (2):273-280. [3] Yinjun L,Jie J,Yungui W.Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells.Leuk Res,2005,29 (1):99-105. [4] Carter BZ,M ak DH,Schober WD,et al.Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.Blood,2006,108 (2):630637. [5] Kim YH,Lee SH,Lee JY,et al.Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase.Eur J Pharmacol,2004,494(1):1-9. [6] Chen P,Li J,Barnes J,et al.Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.J Immunol,2002,169 (11):6408-6416. [7] Miyata Y,Sato T,Ito A.Triptolide,a diterpenoid triepoxide,induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells.Biochem Biophys Res Commun,2005,336(4):1081-1086. [8] Wan CK,Wang C,Cheung HY,et al.Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.Cancer Lett,2006,241 (1):31-41. [9] Frese S,Pirnia F,Miescher D,et al.PG490-mediated sensitization of lung cancer cells to APo2L/TRAIL-induced apoptosis requires activation of ERK2.Oncogene,2003,22 (35):5427-5435. [10] Du ZY,Li XY,Li YC,et al.Analysis of triptolide-regulated gene expression in Jurkat cells by complementary DNA microarray.Acta Pharmacol Sin,2003,24 (9):864-872. [11] Wang CY,Cusack JC Jr,Liu R,et al.Control of inducible chemoresistance:enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.Nat Med,1999,5(4):412-417. [12] Liu H,Liu ZH,Chen ZH,et al.Triptolide:a potent inhibitor of NF-kappa B in T-lymphocytes.Acta Pharmacol Sin,2000,21(9):782-786. [13] Lee KY,Park JS,Jee YK,et al.Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation.Exp Mol Med,2002,34 (6):462-468. [14] Qiu D,Zhao G,Aoki Y,et al.Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation.J Biol Chem,1999,274 (19):13443-13450. [15] Chang WT,Kang JJ,Lee KY,et al.Triptolide and chemotherapy cooperate in tumor cell apoptosis.A role for the p53 pathway.J Biol Chem,2001,276(3):2221-2227. [16] Jiang XH,Wong BC,Lin MC,et al.Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells.Oncogene,2001,20(55):8009-8018. [17] Kiviharju TM,Lecane PS,Sellers RG,et al.Antiproliferative and proapoptotic activities of triptolide (PG490),a natural product entering clinical trials,on primary cultures of human prostatic epithelial cells.Clin Cancer Res,2002,8 (8):2666-2674. [18] Yang S,Chen J,Guo Z,et al.Triptolide inhibits the growth and metastasis of solid tumors.Mol Cancer Ther,2003,2 (1):65-72. [19] Fidler JM,Li K,Chung C,et al.PG490-88,a derivative of triptolide,causes tumor regression and sensitizes tumors to chemotherapy.Mol Cancer Ther,2003,2 (9):855-862. 通讯作者: