国际皮肤性病学杂志    2006 32 (6): 374-376   ISSN: 2096-5540  CN: 32-1880/R   紫外线辐射诱导角质形成细胞凋亡的机制 卞彩云, 蒋献 四川大学华西医院皮肤性病科, 成都610041 收稿日期 2006-03-10  修回日期 null  网络版发布日期 null 参考文献  [1] Lehmann J,Pollet D,Peker S,et al.Kinetics of DNA strand breaks and protection by antioxidants in UVA-or UVB-irradiated HaCaT keratinocytes using the single cell gel electrophoresis assay.Mutat Res,1998,407:97-108. [2] Murphy M,Mabruk MJ,Lenane P,et al.The expression of p53,p21,Bax and induction of apoptosis in normal volunteers in response to different doses of ultraviolet radiation.Br J Dermatol,2002,147:110-117. [3] Oren M.Decision making by p53:life,death and cancer.Cell Death Differ,2003,10:431442. [4] Marchenko ND,Zaika A,Moll UM.Death signal-induced localization of p53 protein to mitochondria.A potential role in apoptotic signaling.J Biol Chem,2000,275:16202-16212. [5] Tron VA,Trotter MJ,Tang L,et al.p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes.Am J Pathol,1998,153:579-585. [6] Bang B,Rygaard J,Baadsgaard O,et al.Increased expression of Fas on human epidermal cells after in vivo exposure to single-dose ultraviolet (UV) B or long-wave UVA radiation.Br J Dermatol,2002,147:1199-1206. [7] Leverkus M,Yaar M,Gilchrest BA.Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes.Exp Cell Res,1997,232:255-262. [8] Kim PK,Weller R,Hua Y,et al.Ultraviolet irradiation increases FADD protein in apoptotic human keratinocytes.Biochem Biophys Res Commun,2003,302:290-295. [9] Assefa Z,Garmyn M,Vantieghem A,et al.Ultraviolet B radiation-induced apoptosis in hman keratinocytes:cytosolic activation of procaspase-8 and the role of Bcl-2.FEBS Lett,2003,540:125-132. [10] Adams JM,Cory S.Life-or-death decisions by the Bcl-2 protein family.Trends Biochem Sci,2001,26:61-66. [11] Cheng EH,Wei MC,Weiler S,et al.BCL-2,BCL-X(L) sequester BH3 domain-only molecules preventing BAX-and BAK-mediated mitochondrial apoptosis.Mol Cell,2001,8:705-711. [12] Rizzuto R,Pinton P,Ferrari D,et al.Calcium and apoptosis:facts and hypotheses.Oncogene,2003,22:8619-8627. [13] Sitailo LA,Tibudan SS,Denning MF.Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes.J Biol Chem,2002,277:19346-19352. [14] Earnshaw WC,Martins LM,Kaufmann SH.Mammalian caspases:structure,activation,substrates,and functions during apoptosis.Annu Rev Biochem,1999,68:383-424. [15] Kyriakis JM,Avruch J.Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.Physiol Rev,2001,81:807-869. [16] Tobiume K,Matsuzawa A,Takahashi T,et al.ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.EMBO Rep,2001,2:222-228. [17] Gulati P,Markova B,Gottlicher M,et al.UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation.EMBO Rep,2004,5:812-817. [18] Gross S,Knebel A,Tenev T,et al.Inactivation ofprotein-tyrosine phosphatases as mechanism of UV-induced signal transduction.J Biol Chem,1999,274:26378-26386. [19] Maziere C,Conte MA,Leborgne L,et al.UVA radiation stimulates ceramide production:relationship to oxidative stress and potential role in ERK,JNK,and p38 activation.Biochem Biophys Res Commun,2001,281:289-294. [20] Shimizu H,Banno Y,Sumi N,et al.Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells.J Invest Dermatol,1999,112:769-774. [21] Van Laethem A,van Kelst S,Lippens S,et al.Activation of p38MAPK is required for Bax translocation to mitochondria,cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes.FASEB J,2004,18:1946-1948. 通讯作者: