国际皮肤性病学杂志    2006 32 (6): 365-367   ISSN: 2096-5540  CN: 32-1880/R   斑秃发病机制的实验研究进展 吴巧云, 郑敏 浙江大学附属第二医院皮肤科, 杭州310009 收稿日期 2006-02-20  修回日期 null  网络版发布日期 null 参考文献  [1] McElwee KJ,Silva K,Beamer WG,et al.Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata.Exp Dermatol,2001,10:420-429. [2] Paus R,Slominski A,Czarnetzki BM.Is alopecia areata an autoimmune-response against melanogenesis-related proteins,exposed by abnormal MHC class I expression in the anagen hair bulb?Yale J Biol Med,1993,66:541-554. [3] McElwee KJ,Boggess D,Burgett B,et al.Murine cytomegalovirus is not associated with alopecia areata in C3H/HeJ mice.J Invest Dermatol,1998,110:986-987. [4] McElwee KJ,Freyschmidt-Paul P,Hoffmann R,et al.Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-)cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model.J Invest Dermatol,2005,124:947-957. [5] McElwee KJ,Silva K,Boggess D,et al.Alopecia areata in C3H/HeJ mice involves leukocyte-mediated root sheath disruption in advance of overt hair loss.Vet Pathol,2003,40:643-650. [6] Zoller M,McElwee KJ,Engel P,et al.Transient CD44 variant isoform expression and reduction in CD4 (+)/CD25 (+) regulatory T cells in C3H/HeJ mice with alopecia areata.J Invest Dermatol,2002,118:983-992. [7] Freyschmidt-Paul P,McElwee KJ,Botchkarev V,et al.Fas-deficient C3.MRL-Tnfrsf6(lpr) mice and Fas ligand-deficient C3H/HeJ-Tnfsf6(gld) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata-affected skin from C3H/HeJ mice.J Investig Dermatol Symp Proc,2003,8:104-108. [8] Freyschmidt-Paul P,McElwee KJ,Hoffmann R,et al.Reduced expression of interleukin-2 decreases the frequency of alopecia areata onset in C3H/HeJ mice.J Invest Dermatol,2005,125:945-951. [9] Ito T,Ito N,Bettermann A,et al.Collapse and restoration of MHC class-I-dependent immune privilege:exploiting the human hair follicle as a model.Am J Pathol,2004,164:623-634. [10] Christoph T,Muller-Rover S,Audring H,et al.The human hair follicle immune system:cellular composition and immune privilege.Br J Dermatol,2000,142:862-873. [11] Gardner S,Freyschmidt-Paul P,Hoffmann R,et al.Normalisation of hair follicle morphology in C3H/HeJ alopecia areata mice after treatment with squaric acid dibutylester.Eur J Dermato,2000,10:443-450. [12] Freyschmidt-Paul P,Seiter S,Zoller M,et al.Treatment with an anti-CD44v10-specific antibody inhibits the onset of alopecia areata in C3H/HeJ mice.J Invest Dermatol,2000,115:653-657. 通讯作者: 郑敏,email:minz@zju.edu.cn