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国际皮肤性病学杂志 2006 32 (6): 359-361 ISSN: 2096-5540 CN: 32-1880/R |
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系统性红斑狼疮的表观遗传学发病机制 |
李亚萍, 陆前进 |
中南大学湘雅二医院皮肤科, 长沙410011 |
收稿日期 2006-01-09 修回日期 null 网络版发布日期 null |
参考文献 [1] Jones PA,Takai D.The role of DNA methylation in mammalian epigenetics.Science,2001,293:1068-1070. [2] Richardson B,Yung R.Role of DNA methylation in the regulation of cell function.J Lab Clin Med,1999,134:333-340. [3] Reik W,Murrell A.Genomic imprinting.Silence across the border.Nature,2000,405:408-409. [4] Bird A.Molecular biology.Methylation talk between histones and DNA.Science,2001,294:2113-2115. [5] Mishra N,Reilly CM,Brown DR,et al.Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.J Clin Invest,2003,111:539-552. [6] Kouskouti A,Talianidis I.Histone modifications defining active genes persist after transcriptional and mitotic inactivation.EMBO J,2005,24:347-357. [7] Turek-Plewa J,Jagodzinski PP.The role of mammalian DNA methyltransferases in the regulation of gene expression.Cell Mol Biol Lett,2005,10:631-647. [8] Huck S,Zouali M.DNA methylation:a potential pathway to abnormal autoreactive lupus B cells.Clin Immunol Immunopathol,1996,80:1-8. [9] Richardson B,Scheinbart L,Strahler J,et al.Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.Arthritis Rheum,1990,33:1665-1673. [10] Quddus J,Johnson KJ,Gavalchin J,et al.Treating activated CD4+T cells with either of two distinct DNA methyltransferase inhibitors,5-azacytidine or procainamide,is sufficient to cause a lupus-like disease in syngeneic mice.J Clin Invest,1993,92:38-53. [11] Deng C,Kaplan MJ,Yang J,et al.Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients.Arthritis Rheum,2001,44:397-407. [12] Lu Q,Kaplan M,Ray D,et al.Demethylation of ITGAL (CD11a)regulatory sequences in systemic lupus erythematosus.Arthritis Rheum,2002,46:1282-1291. [13] Lu Q,Richardson B.Methods for Analyzing the Role of DNA Methylation and Chromatin Structure in Regulating T Lymphocyte Gene Expression.Biol Proced Online,2004,6:189-203. [14] Oelke K,Richardson B.Pathogenesis of lupus.Arthritis Rheum,2002,47:343-345. [15] Deng C,Lu Q,Zhang Z,et al.Hydralazine may induce autoimmunity by inhibiting extracellular sigual-regulated kinase pathway signaling.Arthritis Rheum,2003,48:746-756. [16] Oelke K,Richardson B.Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression.Int Rev Immunol,2004,23:315-331. [17] Lu Q,Wu A,Richardson BC.Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs.J Immunol,2005,174:6212. [18] Bell AC,Felsenfeld G.Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene.Nature,2000,405:482-485. [19] Cedeno S,Cifarelli DF,Blasini AM,et al.Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus:potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells.Clin Immunol,2003,106:41-49. [20] Richardson B.DNA methylation and autoimmune disease.Clin Immunol,2003,109:72-79. |
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