国际皮肤性病学杂志    2006 32 (6): 356-358   ISSN: 2096-5540  CN: 32-1880/R   Toll样受体9与系统性红斑狼疮 方圣, 曾凡钦 中山大学附属第二医院皮肤科, 广州510120 收稿日期 2006-06-13  修回日期 null  网络版发布日期 null 参考文献  [1] Hemmi H,Takeuchi O,Kawai T,et al.A Toll-like receptor recognizes bacterial DNA.Nature,2000,408:740-745. [2] Zarember KA,Godowski PJ.Tissue expression of human Toll-like receptors and differential regulation of Toll-ike receptor mRNAs in leukocytes in response to microbes,their products,and cytokines.J Immunol,2002,168:554-561. [3] Latz E,Schoenemeyer A,Visintin A,et al.TLR9 signals after translocating from the ER to CpG DNA in the lysosome.Nat Immunol,2004,5:190-198. [4] Akira S,Takeda K.Toll-ike receptor signalling.Nat Rev Immunol,2004,4:499-511. [5] Vollmer J,Weeratna R,Payette P,et al.Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.Eur J Immunol,2004,34:251-262. [6] Sato Y,Miyata M,Sato Y,et al.CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro.J Rheumatol,1999,26:294. [7] Gilkeson GS,Pippen AM,Pisetsky DS.Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.J Clin Invest,1995,95:1398. [8] Hemmi H,Takeuchi O,Kawai T,et al.A Toll-like receptor recognizes bacterial DNA.Nature,2000,408:740-745. [9] Rifkin IR,Leadbetter EA,Busconi L,et al.Toll-like receptors,endogenous ligands,and systemic autoimmune disease.Immunol Rev,2005,204:27-42. [10] Pisetsky D,Drayton D,Wu ZQ.Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus.J Rheumatol,1999,26:1934-1938. [11] Bemasconi NL,Onai N,Lanzavecchia A.A role for Toll-like receptors in acquired immunity:up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells.Blood,2003,101:4500-4504. [12] Leadbetter EA,Rifkin IR,Hohlbaum AM,et al.Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-kike receptors.Nature,2002,416:603-607. [13] Viglianti GA,Lau CM,Hanley TM,et al.Activation ofautoreactive B cells by CpG dsDNA.Immunity,2003,19:837-847. [14] Christensen SR,Kashgarian M,Alexopoulou L,et al.Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.J Exp Med,2005,202:321-331. [15] Blanco P,Palucka AK,Gill M,et al.Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.Science,2001,294:1540-1543. [16] Boule MW,Broughton C,Mackay F,et al.Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.J Exp Med,2004,199:1631-1640. [17] Means TK,Latz E,Hayashi F,et al.Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32and TLR9.J Clin Invest,2005,115:407-417. [18] Sparwasser T,Vabulas RM,Villmow B,et al.Bacterial CpG-DNA activates dendritic cells in vivo:T helper cell-independent cytotoxic T cell responses to soluble proteins.Eur J Immunol,2000,30:3591-3597. [19] Ito T,Wang YH,Liu YJ.Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9.Springer Semin Immunopathol,2005,26:221-229. [20] Banchereau J,Pascual V,Palucka AK.Autoimmunity through cytokine-induced dendritic cell activation.Immunity,2004,20:539-550. [21] Vissers JL,van Esch BC,Jeurink PV,et al.Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice.Respir Res,2004,5:21. [22] He B,Qiao X,Cerutti A.CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.J Immunol,2004,173:4479-4491. 通讯作者: