国际皮肤性病学杂志    2006 32 (5): 327-329   ISSN: 2096-5540  CN: 32-1880/R   染色体介导淋球菌耐药机制的进展 蒋法兴, 其木格, 王千秋 中国医学科学院、中国协和医科大学皮肤病研究所, 南京210042 收稿日期 2006-03-30  修回日期 null  网络版发布日期 null 参考文献  [1] Tanaka M,Nakayama H,Notomi T,et al.Antimicrobial resistance of Neisseria gonorrhoeae in Japan,1993-2002:continuous increasing of ciprofloxacin-resistant isolates.Int J Antimicrob Agents,2004,24(Suppl 1):S15-S22. [2] Akasaka S,Muratani T,Yamada Y,et al.Emergence of cephemand aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase.J Infect Chemother,2001,7:49-50. [3] Herida M,Sednaoui P,Goulet V.Gonorrhoea surveillance system in France:1986-2000.Sex Transm Dis,2004,31:209-214. [4] Dillon JA,Ruben M,Li H,et al.Challenges in the control of gonorrhea in South America and the Caribbean:monitoring the development of resistance to antibiotics.Sex Transm Dis,2006,33:87. [5] Ray K,Bala M,Kumari S,et al.Antimicrobial resistance of Neisseria gonorrhoeae in selected World Health Organization Southeast Asia Region countries:an overview.Sex Transm Dis,2005,32:178-184. [6] WHO Western Pacific Gonococcal Antimicrobial Surveillance Programme.Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the World Health Organization Western Pacific Region,2003.Commun Dis Intell,2005,29:62-64. [7] Shigemura K,Shirakawa T,Massi N,et al.Presence of a mutation in ponA1 of Neisseria gonorrhoeae in numerous clinical samples resistant to various beta-lactams and other,structurally unrelated,antimicrobials.J Infect Chernother,2005,11:226-230. [8] Olesky M,Hobbs M,Nicholas RA.Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae.Antimicrob Agents Chemother,2002,46:2811-2820. [9] Ropp PA,Hu M,Olesky M,et al.Mutations in ponA,the gene encoding penicillin-binding protein 1,and a novel locus,penC,are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.Antimicrob Agents Chemother,2002,46:769-777. [10] Zhao S,Tobiason DM,Hu M,et al.The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.Mol Microbiol,2005,57:1238-1251. [11] Veal WL,Nicholas RA,Shafer WM.Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.J Bacteriol,2002,184:5619-5624. [12] Hu M,Nandi S,Davies C,et al.High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants.Antimicrob Agents Chemother,2005,49:4327-4334. [13] Ameyama S,Onodera S,Takahata M,et al.Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime.Antimicrob Agents Chemother,2002,46:3744-3749. [14] Ito M,Deguchi T,Mizutani KS,et al.Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.Antimicrob Agents Chemother,2005,49:137-143. [15] Tanaka M,Nakayama H,Huruya K,et al.Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype.Int J Antimicrob Agents,2006,27:20-26. [16] Dewi BE,Akira S,Hayashi H,et al.High occurrence of simultaneous mutations in target enzymes and MtrRCDE effiux system in quinolone-resistant Neisseria gonorrhoeae.Sex Transm Dis,2004,31:353-359. 通讯作者: