国际皮肤性病学杂志    2006 32 (4): 254-256   ISSN: 2096-5540  CN: 32-1880/R  

CD4+CD25bright调节性T细胞在皮肤病中的作用
赵建斌, 龚匡隆, 王千秋
中国医学科学院、中国协和医科大学皮肤病研究所, 南京 210042
收稿日期 2005-12-05  修回日期 null  网络版发布日期 null
参考文献  [1] Roncarolo MG,Levings MK.The role of different subsets of T regulatory cells in controlling autoimmunity.Curr Opin Immunol,2000,12:676-683.
[2] Belkaid Y,Rouse BT.Natural regulatory T cells in infectious disease.Nat Immunol,2005,6:353-360.
[3] Paust S,Lu L,McCarty N,et al.Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.Proc Natl Acad Sci U S A,2004,101:10398-10403.
[4] von Boehmer H.Mechanisms of suppression by suppressor T cells.Nat Immunol,2005,6:338-344.
[5] Belkaid Y,Piccirillo CA,Mendez S,et al.CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.Nature,2002,420:502-507.
[6] Netea MG,Sutmuller R,Hermann C,et al.Toll-ike receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.J Immunol,2004,172:3712-3718.
[7] Montagnoli C,Bacci A,Bozza S,et al.B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans.J Immunol,2002,169:6298-6308.
[8] Suvas S,Kumaraguru U,Pack CD,et al.CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses.J Exp Med,2003,198:889-901.
[9] Suvas S,Azkur AK,Kim BS,et al.CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions.J Immunol,2004,172:4123-4132.
[10] Weiss L,Donkova-Petrini V,Caccavelli L,et al.Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells,which suppress HIV-specific CD4 T-cell responses in HIV-infected patients.Blood,2004,104:3249-3256.
[11] Aandahl EM,Michaelsson J,Moretto WJ,et al.Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.J Virol,2004,78:2454-2459.
[12] Kinter AL,Hennessey M,Bell A,et al.CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status.J Exp Med,2004,200:331-343.
[13] Crispin JC,Martinez A,Alcocer-Varela J.Quantification of regulatory T cells in patients with systemic lupus erythematosus.J Autoimmun,2003,21:273-276.
[14] Liu MF,Wang CR,Fung LL,et al.Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus.Scand J Immunol,2004,59:198-202.
[15] Viguier M,Lemaitre F,Verola O,et al.Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells.J Immunol,2004,173:1444-1453.
[16] Steitz J,Bruck J,Lenz J,et al.Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced,CD8 (+) T-cell-dependent immune defense of B16 melanoma.Cancer Res,2001,61:8643-8646.
[17] Schaefer C,Kim GG,Albers A,et al.Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer.Br J Cancer,2005,92:913-920.
[18] Sugiyama H,Gyulai R,Toichi E,et al.Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis:mechanism underlying unrestrained pathogenic effector T cell proliferation.J Immunol,2005,174:164-173.
[19] Ou LS,Goleva E,Hall C,et al.T regulatory cells in atopic dermatitis and subversion of their activity by superantigens.J Allergy Clin Immunol,2004,113:756-763.
[20] Vukmanovic-Stejic M,McQuaid A,Birch KE,et al.Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhi-bition of T-cell proliferation in patients with atopic dermatitis.Br J Dermatol,2005,153:750-757.

通讯作者: