国际皮肤性病学杂志    2006 32 (4): 251-253   ISSN: 2096-5540  CN: 32-1880/R   内皮素家族及其受体与恶性黑素瘤 田进, 黄长征, 涂亚庭 华中科技大学同济医学院附属协和医院皮肤科, 武汉 430030 收稿日期 2005-11-30  修回日期 null  网络版发布日期 null 参考文献  [1] Imokawa G,Yada Y,Miyagishi M.Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes.J Biol Chem,1992,267:24675-24680. [2] Brenner M,Degitz K,Besch R,et al.Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation.Br J Dermatol,2005,153:733-739. [3] Demunter A,De Wolf-Peeters C,Degreef H,et al.Expression of the endothelin-B receptor in pigment cell lesions of the skin.Evidence for its role as tumor progression marker in malignant melanoma.Virchows Arch,2001,438:485-491. [4] Bittner M,Meltzer P,Chen Y,et al.Molecular classification of cutaneous malignant melanoma by gene expression profiling.Nature,2000,406:536-540. [5] Bagnato A,Rosano L,Spinella F,et al.Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression.Cancer Res,2004,64:1436-1443. [6] Lahav R.Endothelin receptor B is required for the expansion of melanocyte precursors and malignant melanoma.Int J Dev Biol,2005,49:173-180. [7] Eberle J,Fecker LF,Orfanos CE,et al.Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines.J Invest Dermatol,2002,119:549-555. [8] McGill GG,Horstmann M,Widlund HR,et al.Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.Cell,2002,109:707-718. [9] Lahav R,Suva ML,Rimoldi D,et al.Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas.Cancer Res,2004,64:8945-8953. [10] Hsu MY,Meier FE,Nesbit M,et al.E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors.Am J Pathol,2000,156:1515-1525. [11] Hsu M,Andl T,Li G,et al.Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression.J Cell Sci,2000,113(Pt 9):1535-1542. [12] Poser I,Dominguez D,de Herreros AG,et al.Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail.J Biol Chem,2001,276:24661-24666. [13] Mangahas CR,dela Cruz GV,Schneider RJ,et al.Endothelin-1 upregulates MCAM in melanocytes.J Invest Dermatol,2004,123:1135-1139. [14] Rivedal E,Opsahl H.Role of PKC and MAP kinase in EGF-and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells.Carcinogenesis,2001,22:1543-1550. [15] Brinckerhoff CE,Matrisian LM.Matrix metalloproteinases:a tail of a frog that became a prince.Nat Rev Mol Cell Biol,2002,3:207-214. [16] Bemardo MM,Fridman R.TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.BiochemJ,2003,374 (Pt 3):739-745. [17] Ma LJ,Liu LY,Jiao S,et al.Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells.Pigment Cell Res,2003,16:463-469. [18] Liu LY,Hu CL,Ma LJ,et al.ET-1 inhibits B-16 murine melanoma cell migration by decreasing K(+) currents.Cell Motil Cytoskeleton,2004,58:127-136. [19] Kahana O,Micksche M,Witz IP,et al.The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma.Oncogene,2002,21:3969-3977. [20] Satyamoorthy K,Li G,Gerrero MR,et al.Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.Cancer Res,2003,63:756-759. [21] Smalley KS.A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer,2003,104:527-532. [22] Mangahas CR,dela Cruz GV,Friedman-Jimenez G,et al.Endothelin-1 induces CXCL1 and CXCL8 secretion in human melanoma cells.J Invest Dermatol,2005,125:307-311. 通讯作者: