国际皮肤性病学杂志    2006 32 (3): 179-181   ISSN: 2096-5540  CN: 32-1880/R   银屑病与细胞凋亡 张正中1, 张学军1, 杨森1, 眭维耻2 1. 安徽医科大学皮肤病研究所、第一附属医院皮肤科 合肥 230022; 2. 四川省南充市川北医学院附属医院皮肤性病科 收稿日期 2005-10-09  修回日期 null  网络版发布日期 null 参考文献  [1] Laporte M,Galand P,Fokan D,et al.Apoptosis in established and healing psoriasis.Dermatology,2000,200:314-316. [2] Bianchi L,Farrace MG,Nini G,et al.Abnormal Bcl-2 and "tissue"transglutaminase expression in psoriatic skin.J Invest Dermatol,1994,103:829-833. [3] Wrone-Smith T,Johnson T,Nelson B,et al.Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo.Am J Pathol,1995,146:1079-1088. [4] Kanerva L.Electron microscopy of the effects of dithranol on healthy and on psoriatic skin.Am J Dermatopathol,1990,12:51. [5] Kawashima K,Doi H,Ito Y,et al.Evaluation of cell death and proliferation in psoriatic epidermis.J Dermatol Sci,2004,35:207. [6] Yamamoto T,Nishioka K.Alteration of the expression of Bcl-2,Bcl-x,Bax,Fas,and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy.Skin Pharmacol Appl Skin Physiol,2003,16:50-58. [7] Kocak M,Bozdogan O,Erkek E,et al.Examination of Bcl-2,Bcl-X and bax protein expression in psoriasis.Int J Dermatol,2003,42:789-793. [8] Yildiz L,Baris S,Senturk N,et al.Overexpression of bcl-2 in lymphocytes of psoriatic skin.J Eur Acad Dermatol Venereol,2003,17:538-540. [9] Takahashi H,Manabe A,Ishida-Yamamoto A,et al.Aberrant expression of apoptosis-related molecules in psoriatic epidermis.J Dermatol Sci,2002,28:187-197. [10] Chiarugi V,Ruggiero M.Role of three cancer "master genes" p53,bcl2 and c-myc on the apoptotic process.Tumori,1996,82:205. [11] Heenen M,Laporte M,Noel JC,et al.Methotrexate induces apoptotic cell death in human keratinocytes.Arch Dermatol Res,1998,290:240-245. [12] Banno T,Gazel A,Blumenberg M.Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling.I Biol Chem,2004,279:32633. [13] Jost M,Class R,Kari C,et al.A central role of Bcl-X(L) in the regulation of keratinocyte survival by autocrine EGFR ligands.J Invest Dermatol,1999,112:443-449. [14] Tomkova H,Fujimoto W,Arata J.Expression pattern of the bcl-2 homologous protein bad in normal skin,psoriasis vulgaris and keratinocytic tumors.J Dermatol Sci,2000,22:132-137. [15] Waring P,Mullbacher A.Cell death induced by the Fas/Fas ligand pathway and its role in pathology.Immunol Cell Biol,1999,77:312-317. [16] Cataisson C,Joseloff E,Murillas R,et al.Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways.J Immunol,2003,171:2703-2713. [17] Chen SH,Arany I,Apisarnthanarax N,et al.Response of keratinocytes from normal and psoriatic epidermis to interferon-gamma differs in the expression of zinc-alpha (2)-glycoprotein and cathepsin D.FASEB J,2000,14:565-571. [18] Santamaria AB,Davis DW,Nghiem DX,et al.p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells.Cell Death Differ,2002,9:549-560. [19] Deng H,Yan CL,Hu Y,et al.Photochemotherapy inhibits angiogenesis and induces apoptosis of endothelial cells in vitro.Photodermatol Photoimmunol Photomed,2004,20:191-199. [20] Sugie N,Fujii N,Danno K.Cyclosporin-A suppresses p53-dependent repair DNA synthesis and apoptosis following ultraviolet-B irradiation.Photodermatol Photoimmunol Photomed,2002,18:163. [21] Smit JV,de Jong EM,van Hooijdonk CA,et al.Systemic treatment of psoriatic patients with bexarotene decreases epidermal proliferation and parameters for inflammation,and improves differentiation in lesional skin.J Am Acad Dermatol,2004,51:257. [22] Fukuya Y,Higaki M,Higaki Y,et al.Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis.Arch Dermatol Res,2002,293:620-625. [23] Lippens S,Kockx M,Denecker G,et al.Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.Am J Pathol,2004,165:833. [24] McGill A,Frank A,Emmett N,et al The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria,dissipates mitochondrial membrane potential,and induces apoptosis through a pathway dependent on respiratory competent mitochondria.FASEB J,2005,19:1012-1014. [25] Heenen M,Laporte M,Noel JC,et al.Methotrexate induces apoptotic cell death in human keratinocytes.Arch Dermatol Res,1998,290:240-245. 通讯作者: