国际皮肤性病学杂志    2006 32 (1): 48-50   ISSN: 2096-5540  CN: 32-1880/R   存活素和皮肤病 邵黎明, 朱可建 浙江大学医学院附属邵逸夫医院皮肤科, 杭州310016 收稿日期 2005-04-07  修回日期 null  网络版发布日期 null 参考文献  [1] Ambrosini G,Adida C,Altieri DC.A novel anti-apoptosis gene,survivin,expressed in cancer and lymphoma.Nat Med,1997,3:917-921. [2] Verdecia MA,Huang H,Dutil E,et al.Structure of the human antiapoptotic protein survivin reveals a dimeric arrangement.Nat Struct Biol,2000,7:602-608. [3] Conway EM,Pollefeyt S,Cornelissen J,et al.Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.Blood,2000,95:1435-1442. [4] Johnson ME,Howerth EW.Survivin:a bifunctional inhibitor of apoptosis protein.Vet Pathol,2004,41:599-607. [5] Mahotka C,Liebmann J,Wenzel M,et al.Differential subcellular localization of functionally divergent survivin splice variants.Cell Death Differ,2002,9:1334-1342. [6] O'Connor DS,Grossman D,Plescia J,et al.Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.Proc Natl Acad Sci U S A,2000,97:13103-13107. [7] Marusawa H,Matsuzawa S,Welsh K,et al.HBXIP functions as a cofactor of survivin in apoptosis suppression.EMBO J,2003,22:2729-2740. [8] Wang Z,Fukuda S,Pelus LM.Survivin regulates the p53 tumor suppressor gene family.Oncogene,2004,23:8146-8153. [9] Yang D,Welm A,Bishop JM.Cell division and cell survival in the absence of survivin.Proc Natl Acad Sci U S A,2004,101:15100-15105. [10] Grossman D,Kim PJ,Blanc-Brude OP,et al.Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.J Clin Invest,2001,108:991-999. [11] Grossman D,McNiff JM,Li F,et al.Expression of the apoptosis inhibitor,survivin,in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.Lab Invest,1999,79:1121-1126. [12] Allen SM,Florell SR,Hanks AN,et al.Survivin expression in mouse skin prevents papilloma regression and promotes chemicalinduced tumor progression.Cancer Res,2003,63:567-372. [13] Bowen AR,Hanks AN,Murphy KJ,et al.Proliferation,apoptosis,and survivin expression in keratinocytic neoplasms and hyperplasias.Am J Dermatopathol,2004,26:177-181. [14] Park HR,Min SK,Cho HD,et al.Expression profiles of p63,p53,survivin,and hTERT in skin tumors.J Cutan Pathol,2004,31:544-549. [15] Lo Muzio L,Staibano S,Pannone G,et al.Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma.Exp Mol Pathol,2001,70:249-254. [16] Grossman D,Altieri DC.Drug resistance in melanoma:mechanisms,apoptosis,and new potential therapeutic targets.Cancer Metastasis Rev,2001,20:3-1 l. [17] Grossman D,Kim PJ,Schechner JS,et al.Inhibition of melanoma tumor growth in vivo by survivin targeting.Proc Natl Acad Sci U S A,2001,98:635-640. 通讯作者: 朱可建,E-mail:zhukejian@mail.hz.zj.cn