国际皮肤性病学杂志    2006 32 (1): 32-34   ISSN: 2096-5540  CN: 32-1880/R   特应性皮炎小鼠模型研究进展 董正邦, 张美华 南京医科大学第一附属医院皮肤性病科, 210029 收稿日期 2005-06-24  修回日期 null  网络版发布日期 null 参考文献  [1] Leung DY,Boguniewicz M,Howell MD,et al.New insights into atopic dermatitis.J Clin Invest,2004,113:651-657. [2] Leung DY,Bieber T.Atopic dermatitis.Lancet,2003,361:151-160. [3] Shiohara T,Hayakawa J,Mizukawa Y.Animal models for atopic dermatitis:are they relevant to human disease? J Dermatol Sci,2004,36:1-9. [4] Sugiura K,Hiramoto K,Shamoto M,et al.Immunological cell situation in the skin of atopic model mice.J Eur Acad Dermatol Venereol,2004,18:148-152. [5] Hashimoto Y,Kaneda Y,Akashi T,et al.Persistence of Staphylococcus aureus colonization on the skin of NC/Nga mice.J Dermatol Sci,2004,35:143-150. [6] Matsuoka H,Maki N,Yoshida S,et al.A mouse model of the atopic eczema/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae.Allergy,2003,58:139-145. [7] Kohara Y,Tanabe K,Matsuoka K,et al.A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9.Immunogenetics,2001,53:15-21. [8] Hikita I,Yoshioka T,Mizoguchi T,et al.Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions:another possible model for atopic dermatitis.J Dermatol Sci,2002,30:142-153. [9] Watanabe A,Takeuchi M,Nagata M,et al.Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions.Exp Anim,2003,52:77-80. [10] Watanabe A,Takeuchi M,Nagata M,et al.Role of the Nh (Nonhair) mutation in the development of dermatitis and hyperproduction of IgE in DS-Nh mice.Exp Anim,2003,52:419-423. [11] Matsukura S,Aihara M,Hirasawa T,et al.Effects of TNCB sensitization in DS-Nh mice,serving as a model of atopic dermatitis,in comparison with NC/Nga mice.Int Arch Allergy Immunol,2005,136:173-180. [12] Kitagaki H,Fujisawa S,Watanabe K,et al.Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice.J Invest Dermatol,1995,105:749-755. [13] Matsumoto K,Mizukoshi K,Oyobikawa M,et al.Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum,corneum with various non-invasive biophysical instruments.Skin Res Technol,2004,10:122. [14] Spergel JM,Mizoguchi E,Brewer JP,et al.Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.J Clin Invest,1998,101:1614-1622. [15] Laouini D,Kawamoto S,Yalcindag A,et al.Epicutaneous sensitization with superantigen induces allergic skin inflammation.J Allergy Clin Immunol,2003,112:981-987. [16] Takeshita K,Yamasaki T,Akira S,et al.Essential role of MHC II-independent CD4+ T cells,IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.Int Immunol,2004,16:685-695. [17] Li XM,Kleiner G,Huang CK,et al.Murinemodel of atopic dermatitis associated with food hypersensitivity.J Allergy Clin Immunol,2001,107:693-702. [18] Chan LS,Robinson N,Xu L.Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease:an experimental animal model to study atopic dermatitis.J Invest Dermatol,2001,117:977-983. [19] Chen L,Martinez O,Overbergh L,et al.Early up-regulation of Th2 cytokines and late surge of Thl cytokines in an atopic dermatitis model.Clin Exp Immunol,2004,138:375-387. [20] Konishi H,Tsutsui H,Murakami T,et al.IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.Proc Natl Acad Sci U S A,2002,99:11340-11345. [21] Yagi R,Nagai H,Iigo Y,et al.Development of atopic dermatitislike skin lesions in STAT6-deficient NC/Nga mice.J Immunol,2002,168:2020-2027. [22] Spergel JM,Mizoguchi E,Oettgen H,et al.Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.J Clin Invest,1999,103:1103-1111. [23] Laouini D,Alenius H,Bryce P,et al.IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.J Clin Invest,2003,112:1058-1066. 通讯作者: