国际皮肤性病学杂志    2006 32 (1): 16-19   ISSN: 2096-5540  CN: 32-1880/R   表没食子儿茶精没食子酸酯皮肤光保护作用机制研究进展 徐丽贤, 骆丹 南京医科大学第一附属医院皮肤科, 210029 收稿日期 2005-06-27  修回日期 null  网络版发布日期 null 参考文献  [1] Elmets CA,Singh D,Tubesing K,et al.Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.J Am Acad Dermatol,2001,44:425-432. [2] Katiyar SK,Mukhtar H.Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes,depletion of antigen-presenting cells,and oxidative stress.J Leukoc Biol,2001,69:719-726. [3] Katiyar SK,Matsui MS,Elmets CA,et al.Polyphenolic antioxidant(-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin.Photochem Photobiol,1999,69:148-153. [4] Katiyar SK,Afaq F,Perez A,et al.Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.Carcinogenesis,2001,22:287-294. [5] Wei H,Zhang X,Zhao JF,et al.Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green and black teas.Free Radic Biol Med,1999,26:1427-1435. [6] Katiyar SK,Bergamo BM,Vyalil PK,et al.Green tea polyphenols:DNA photodamage and photoimmunology.J Photochem Photobiol B,2001,65:109-114. [7] Katiyar SK,Challa A,McCormick TS,et al.Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production.Carcinogenesis,1999,20:2117-2124. [8] Katiyar SK.Skin photoprotection by green tea:antioxidant and immunomodulatory effects.Curr Drug Targets Immune Endocr Metabol Disord,2003,3:234-242. [9] Goukassian DA,Helms E,van Steeg H,et al.Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.Proc Natl Acad Sci U S A,2004,101:3933-3938. [10] Mittal A,Piyathilake C,Hara Y,et al.Exceptionally high protection of photocarcinogenesis by topical application of (-)-epigallocate-chin-3-gallate in hydrophilic cream in SKH-1 hairless mousemodel:relationship to inhibition of UVB-induced global DNA hy-pomethylation.Neoplasia,2003,5:555-565. [11] Morley N,Clifford T,Salter L,et al.The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellularDNA from ultraviolet and visible radiation-induced damage.Photo-dermatol Photoimmunol Photomed,2005,21:15-22. [12] Chen W,Dong Z,Valcic S,et al.Inhibition of ultraviolet B-inducedc-fos gene expression and p38 mitogen-activated protein kinase ac-tivation by (-)-epigallocatechin gallate in a human keratinocyte cellline.Mol Carcinog,1999,24:79-84. [13] Kim J,Hwang JS,Cho YK,et al.Protective effects of (-)-epigallo-catechin-3-gallate on UVA-and UVB-induced skin damage.SkinPharmacol Appl Skin Physiol,2001,14:11-19. [14] Afaq F,Adhami VM,Ahmad N,et al.Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epi-dermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate.Oncogene,2003,22:1035-1044. [15] Einspahr JG,Bowden GT,Alberts DS.Skin cancer chemopreven-tion:strategies to save our skin.Recent Results Cancer Res,2003,163:151-164. [16] Lu YP,Lou YR,Xie JG,et al.Topical applications of caffeine or(-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and se-lectively increase apoptosis in UYB-induced skin tumors in mice.Proc Natl Acad Sci U S A,2002,99:12455-12560. [17] Lin JK,Liang YC.Cancer chemoprevention by tea polyphenols.Proc Natl Sci Counc Repub China B,2000,24:1-13. [18] Katiyar SK,Elmets CA.Green tea polyphenolic antioxidants andskin photoprotection (Review).Int J Oncol,2001,18:1307-1313. 通讯作者: