国际皮肤性病学杂志    2005 31 (4): 232-234   ISSN: 2096-5540  CN: 32-1880/R   T细胞DNA低甲基化在SLE的研究进展 丁艳1, 肖嵘1, 李亚萍1, 文海泉1, 陆前进2 1. 中南大学湘雅二医院皮肤科, 长沙410011; 2. 美国密歇根大学医学研究中心 收稿日期 2004-08-17  修回日期 null  网络版发布日期 null 参考文献  [1] Deng C, Kaplan MJ, Yang J, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum, 2001,44:397-407. [2] Lu Q, Kaplan M, Ray D, et al. Demethylation of ITGAL (CD11a)regulatory sequences in systemic lupus erythematosus. Arthritis Rheum, 2002, 46:1282-1291. [3] Yung R, Powers D, Johnson K, et al. Mechanisms of drug-induced lupus. Ⅱ. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest, 1996, 97:2866-2871. [4] Deng C, Lu Q, Zhang Z,et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling.Arthritis Rheum, 2003, 48:746-756. [5] Scheinbart LS, Johnson MA, Gross LA, et al. Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol, 1991,18:530-534. [6] Richardson BC, Strahler JR, Pivirotto TS, et al. Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus. Arthritis Rheum, 1992, 35:647-662. [7] Bird JJ, Brown DR, Mullen AC, et al. Helper T cell differentiation is controlled by the cell cycle. Immunity, 1998, 9:229-237. [8] Lu Q, Wu A, Ray D, et al. DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol, 2003,170:5124-5132. [9] Hynes RO. Integrins: bidirectional, allosteric signaling machines.Cell, 2002, 110:673-687. [10] Petruzzelli L, Takami M, Herrera R. Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkⅡ. J Biol Chem, 1996, 271:7796-7801. [11] Clark SJ, Harrison J, Paul CL, et al. High sensitivity mapping of methylated cytosines.Nucleic Acids Res, 1994, 22:2990-2997. [12] Kaplan MJ, Deng C, Yang J, et al. DNA methylation in the regulation of T cell LFA-1 expression. Immunol Invest, 2000, 29:411-425. [13] Takeuchi T, Amano K, Sekine H, et al. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Invest, 1993, 92:3008-3016. [14] Lu Q, Ray D, Gutsch D, et al. Effect of DNA methylation and chromatin structure on ITGAL expression. Blood, 2002, 99:4503-4508. [15] Nakamura T, Ebihara I, Tomino Y, et al. Perforin mRNA expression in the inflamed tissues of NZB/W F1 lupus mice decreases with methylprednisolone treatment. Am J Pathol, 1991, 139:731-736. [16] Lens SM, Tesselaar K, van Oers MH, et al. Control of lymphocyte function through CD27-CD70 interactions. Semin Immunol, 1998,10:491-499. [17] Oelke K, Lu Q, Richardson D, et al. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum, 2004, 50:1850-1860. [18] Kobata T, Jacquot S, Kozlowski S, et al. CD27-CD70 interactions regulate B-cell activation by T cells. Proc Natl Acad Sci U S A,1995, 92:11249-11253. [19] Deng C, Kaplan M J, Yang J, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum, 2001,44:397-407. 通讯作者: