国际皮肤性病学杂志    2005 31 (2): 119-121   ISSN: 2096-5540  CN: 32-1880/R   Wnt信号转导通路及其在皮肤肿瘤中的作用 殷河慧, 廖文俊 第四军医大学西京医院全军皮肤性病中心 西安 710032 收稿日期 2004-06-22  修回日期 null  网络版发布日期 null 参考文献  [1] Huelsken J, Birchmeier W. New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev, 2001, 11:547-553. [2] Pham K, Milovanovic T, Barr RJ, et al. Wnt ligand expression in malignant melanoma: pilot study indicating correlation with histopathological features. Mol Pathol, 2003, 56:280-285. [3] Weeraratna AT, Jiang Y, Hostetter G,et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell, 2002, 1:279-288. [4] Demunter A, Libbrecht L, Degreef H,et al. Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.Mod Pathol. 2002, 15:454-461. [5] Maelandsmo GM, Holm R, Nesland JM, et al. Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma. Clin Cancer Res, 2003, 9:3383-3388. [6] Rubinfeld B, Robbins P, El-Gamil M,et al. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science, 1997, 275:1790-1792. [7] Omholt K, Platz A, Ringborg U, et al. Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer, 2001, 92:839. [8] Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, et al. Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev, 2002, 16:2058-2072. [9] Murakami T, Toda S, Fujimoto M,et al. Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential. Biochem Biophys Res Commun, 2001, 288:8-15. [10] Yamazaki F, Aragane Y, Kawada A, et al. Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma. Br J Dermatol, 2001, 145:771-777. [11] Lo Muzio L, Pannone G, Staibano S, et al. WNT-1 expression in basal cell carcinoma of head and neck. An immunohistochemical and confocal study with regard to the intracellular distribution of beta-catenin. Anticancer Res, 2002, 22:565-576. [12] Boonchai W, Walsh M, Cummings M, et al. Expression of beta-catenin, a key mediator of the WNT signaling pathway, in basal cell carcinoma. Arch Dermatol, 2000, 136:937-938. [13] Hassanein AM, Glanz SM. Beta-catenin expression in benign and malignant pilomatrix neoplasms. Br J Dermatol, 2004, 150:511-516. 通讯作者: