国际皮肤性病学杂志    2005 31 (2): 116-118   ISSN: 2096-5540  CN: 32-1880/R  

微透析与经皮药代动力学
隗慧林, 陈沄
中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042
收稿日期 2004-04-16  修回日期 null  网络版发布日期 null
参考文献  [1] Muller M. Science, medicine, and the future: Microdialysis. BMJ, 2002, 324:588-591.
[2] Anderson C, Andersson T, Molander M,et al. Ethanol absorption across human skin measured by in vivo microdialysis technique.Acta Derm Venereol(Stockh),1991,71:389-393.
[3] Groth L. Cutaneous microdialysis. Methodology and validation. Acta Derm Venereol (Stockh), 1996 , 197(Suppl):1-61.
[4] Groth L, Serup J. Cutaneous microdialysis in man: effects of needle insertion trauma and anaesthesia on skin perfusion, erythema and skin thickness. Acta Derm Venereol(Stockh), 1998, 78:5-9.
[5] Morgan CJ, Renwick AG, Friedmann PS. The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis. Br J Dermatol, 2003, 148:434-443.
[6] Benfeldt E, Serup J, Menne T. Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Br J Dermatol, 1999, 140:739-748.
[7] Murakami T, Yoshioka M, Okamoto I, et al. Effect of ointment bases on topical and transdermal delivery of salicylic acid in rats: evaluation by skin microdialysis. J Pharm Pharmacol, 1998, 50:55-61.
[8] Benfeldt E, Serup J, Menne T. Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis. Acta Derm Venereol, 1999, 79:338-342.
[9] Hegemann L, Forstinger C, Partsch B, et al. Microdialysis in cutaneous pharmacology: kinetic analysis of transdermally delivered nicotine. J Invest Dermatol, 1995, 104:839-843.
[10] Boelsma E, Anderson C, Karlsson AM, et al. Microdialysis technique as a method to study the percutaneous penetration of methyl nicotinate through excised human skin, reconstructed epidermis, and human skin in vivo. Pharm Res, 2000, 17:141-147.
[11] Stagni G, O'Donnell D, Liu YJ, et al. Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis. J Control Release, 2000, 63:331-339.
[12] Tegeder I, Muth-Selbach U, Lotsch J, et al. Application of microdia-lysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration. Clin Pharmacol Ther, 1999, 65:357-368.
[13] Joukhadar C, Stass H, Muller-Zellenberg U, et al. Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans. Antimicrob Agents Chemother, 2003, 47:3099-3103.
[14] Bielecka-Grzela S, Klimowicz A. Evaluation of ofloxacin penetration into the skin after a single oral dose assessed by cutaneous microdialysis. Pol J Pharmacol, 2003, 55:613-618.
[15] Frossard M, Joukhadar C, Erovic BM, et al. Distribution and antimicrobial activity of fosfomycin in the interstitial fluid of human soft tissues. Antimicrob Agents Chemother, 2000, 44:2728-2732.
[16] Kreilgaard M. Assessment of cutaneous drug delivery using microdialysis. Adv Drug Deliv Rev, 2002, 54:S99-S121.
[17] Tegeder I, Brautigam L, Podda M, et al. Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen. Clin Pharmacol Ther, 2002, 71:153-161.
[18] Kreilgaard M, Kemme MJ, Burggraaf J, et al. Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics. Pharm Res, 2001, 18:593-599.
[19] Brunner M, Stabeta H, Moller JG, et al. Target site concentrations of ciprofloxacin after single intravenous and oral doses. Antimicrob Agents Chemother, 2002, 46:3724-3730.

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