国际皮肤性病学杂志    2004 30 (6): 369-371   ISSN: 2096-5540  CN: 32-1880/R  

金黄色葡萄球菌超抗原在特应性皮炎发病中的作用研究进展
陈文琦, 张美华
南京医科大学第一附属医院皮肤科 210029
收稿日期 2004-02-11  修回日期 null  网络版发布日期 null
参考文献  [1] Zollner TM, Wichelhaus TA, Hartung A,et al. Colonization with superantigen-producing Staphylococcus aureus is associated with increased severity of atopic dermatitis. Clin Exp Allergy, 2000, 30:994-1000.
[2] Bunikowski R, Mielke ME, Skarabis H, et al. Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis. J Allergy Clin Immunol, 2000, 105:814-819.
[3] Bunikowski R, Mielke M, Skarabis H, et al. Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis. J Allergy Clin Immunol, 1999,103:119-124.
[4] Skov L, Olsen JV, Giorno R, et al. Application of Staphylococcal enterotoxin B on normal and atopic skin induces up-regulation of T cells by a superantigen-mediated mechanism. J Allergy Clin Immunol,2000, 105:820-826.
[5] Laouini D, Kawamoto S, Yalcindag A, et al. Epicutaneous sensitization with superantigen induces allergic skin inflamnation. J Allergy Clin Immunol, 2003, 112:981-987.
[6] Davison S, Allen M, Vaughan R, et al. Staphylococcal toxin-induced T cell proliferation in atopic eczema correlates with increased use of superantigen-reactive Vbeta-chains in cutaneous lymphocyte-associated antigen (CLA)-positive lymphocytes. Clin Exp Immunol, 2000,121:181-186.
[7] Yoshioka T, Hikita I, Matsutani T,et al. DS-Nh as an experimental model of atopic dermatitis induced by Staphylococcus aureus producing staphylococcal enterotoxin C. Immunology, 2003, 108:562-569.
[8] Konig B, Neuber K, Konig W. Responsiveness of peripheral blood mononuclear cells from normal and atopic donors to microbial superantigens, Int Arch Allergy Immunol, 1995, 106:124-133.
[9] Yoshino T, Asada H, Sano S, et al. Impaired responses of peripheral blood mononuclear cells to staphylococcal superantigen in patients with severe atopic dermatitis: a role of T cell apoptosis. J Invest Dermatol,2000, 114:281-288.
[10] Heaton T, Mallon D, Venaille T, et al. Staphylococcal enterotoxin induced IL-5 stimulation as a cofactor in the pathogenesis of atopic disease: the hygiene hypothesis in reverse? Allergy, 2003, 58:252-256.
[11] Wedi B, Wieczorek D, Stunkel T,et al. Staphylococcal exotoxins exert proinflammatory effects through inhibition of eosiuophil apoptosis,increased surface antigen expression (CDllb, CD45, CD54, and CD69), and enhanced cytokine-activated oxidative burst, thereby triggering allergic inflammatory reactions. J Allergy Clin Immunol,2002, 109:477-484.
[12] Hauk PJ, Hamid QA, Chrousos GP, et al. Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens. J Allergy Clin Immunol, 2000, 105:782-787.
[13] Matsuda H, Watanabe N, Geba GP, et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice.Int Immunol, 1997, 9:461-466.
[14] Herz U, Schnoy N, Borelli S,et al. A human-SCID mouse model for allergic immune response bacterial superantigen enhances skin inflammation and suppresses lgE production. J Invest Dermatol, 1998, 110:224-231.
[15] Matsui K, Nishikawa A, Suto H, et al. Comparative study of Staphylococcus aureus isolated from lesional and non-lesional skin of atopic dermatitis patients. Microbiol Immunol, 2000,44:945-947.
[16] Akiyama H, Tot Y, Kanzaki H, et al. Prevalence of producers of enterotoxins and toxic shock syndrome toxin-1 among Staphylococcus aureus strains isolated from atopic dermatitis lesions. Arch Dermatol Res, 1996, 288:418-420.
[17] Leung DY, Harbeck R, Bina P, et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis.Evidence for a new group of allergens. J Clin Invest, 1993, 92:1374-1380.

通讯作者: