国际皮肤性病学杂志    2004 30 (6): 360-362   ISSN: 2096-5540  CN: 32-1880/R  

CpG DNA在系统性红斑狼疮发病中的作用
鲁智勇, 沈小雁, 郑捷
上海第二医科大学附属瑞金医院皮肤科 200025
收稿日期 2004-01-06  修回日期 null  网络版发布日期 null
参考文献  [1] Krieg AM. CpG DNA: a pathogenic factor in systemic lupus erythematosus? J Clin Immunol, 1995, 15:284-292.
[2] Sato Y, Miyata M, Sato Y, et al. CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro. J Rheumatol, 1999, 26:294-301.
[3] Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature, 2000, 408:740-745.
[4] Bernasconi NL, Onai N, Lanzavecchia A. A role for Toil-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood,2003, 101:4500-4504.
[5] Hornung V, Rothenfusser S, Britsch S, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol, 2002, 168:4531-4537.
[6] Elkins KL, Rhinehart-Jones TR, Stibitz S, et al. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol, 1999,162:2291-2298.
[7] Verthelyi D, Ishii KJ, Gursel M, et al. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J Immunol, 2001,166:2372-2377.
[8] Sato Y, Miyata M, Sato Y, et al. CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro. J Rheumatol, 1999, 26:294-301.
[9] Napirei M, Karsunky H, Zevnik B, et al. Features of systemic lupus erythematosus in Dnasel-deficient mice. Nat Genet, 2000, 25:177-181.
[10] Leadbetter EA, Rifkin IR, Hohlbaum AM,et al. Chromatin-lgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature, 2002, 416:603-607.
[11] Lenert P, Goeken A, Handwerger BS, et al. Innate immune responses in lupus-prone Palmerston North mice: differential responses to LPS and bacterial DNA/CpG oligonucleotides. J Clin Immunol, 2003, 23:202-213.
[12] Zonana-Nacach A, Camargo-Coronel A, Yanez P,et al. Infections in outpatients with systemic lupus erythematosus: a prospective study.Lupus, 2001,10:505-510.
[13] Scheinecker C, Zwolfer B, Koller M, et al. Alterations of dendritic cells in systemic lupus erythematosus: phenotypic and functional deficiencies. Arthritis Rheum, 2001, 44:856-865.
[14] Zeuner RA, Klinman DM, Illei G,et al. Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides. Rheumatology (Oxford), 2003, 42:563-569.
[15] Gilkeson GS, Pippen AM, Pisetsky DS. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest, 1995, 95:1398-1402.
[16] Rui L, Vinuesa CG, Blasioli J, et al. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat Immunol, 2003, 4:594-600.
[17] Deng C, Kaplan MJ, Yang J,et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum, 2001, 44:397-407.
[18] Pisetsky D, Drayton D, Wu ZQ. Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus. J Rheumatol, 1999, 26:1934-1938.
[19] Ichikawa HT, Williams LP, Segal BM. Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease. J Immunol, 2002, 169:2781-2787.
[20] Miyata M, Ito O, Kobayashi H, et al. CpG-DNA derived from sera in systemic lupus erythematosus enhances ICAM-1 expression on endothelial cells. Ann Rheum Dis, 2001, 60:685-689.
[21] Golbus J, Palella TD, Richardson BC. Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol, 1990, 20:1869-1872.
[22] Anders HJ, Banas B, Linde Y,et al. Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol,2003, 14:317-326.

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