国际皮肤性病学杂志    2004 30 (4): 247-249   ISSN: 2096-5540  CN: 32-1880/R   BRAF蛋白与恶性黑素瘤 林彤, 孙建方 中国医学科学院、中国协和医科大学皮肤病研究所, 南京210042 收稿日期 2003-09-10  修回日期 null  网络版发布日期 null 参考文献  [1] Kolch W, Kotwaliwale A, Vass K,et al. The role of Raf kinases in malignant transformation. Expert Rev Mol Med, 2002, 2002:1-18. [2] Zhang W, Liu HT. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res, 2002, 12:9-18. [3] Storm SM, Brennscheidt U, Sithanandam G, et al. Raf oncogenes in carcinogenesis. Crit Rev Oncog, 1990, 2:1-8. [4] Tzivion G, Luo Z, Avruch J. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature, 1998, 394:88-92. [5] Vossler MR, Yao H, York RD, et al. cAMP activates MAP kinase and Elk-1 through a B-Raf-and Rapl-dependent pathway. Cell,1997, 89:73-82. [6] Okada T, Hu CD, Jin TG, et al. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases. Mol Cell Biol, 1999, 19:6057-6064. [7] Houslay MD, Kolch W. Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. Mol Pharrnacol, 2000, 58:659-668. [8] Saxena M, Williams S, Tasken K,et al. Crosstalk between cAMP-de-pendent kinase and MAP kinase through a protein tyrosine phosphatase. Nat Cell Biol, 1999, 1:305-311. [9] Frodin M, Peraldi P, Van Obberghen E. Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J Biol Chem,1994, 269:6207-6214. [10] Englaro W, Rezzonico R, Durand-Clement M, et al. Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-in-duced melanogenesis in B-16 melanoma cells. J Biol Chem, 1995,270:24315-24320. [11] Mason CS, Springer CJ, Cooper RG,et al. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J,1999, 18:2137-2148. [12] Busca R, Abbe P, Mantoux F, et al. Ras mediates the cAMP-de-pendent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J, 2000, 19:2900-2910. [13] Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature, 2002,417:949-954. [14] Brose MS, Volpe P, Feldman M, et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res, 2002, 62:6997-7000. [15] Pollock PM, Harper UL, Hansen KS,et al. High frequency of BRAF mutations in nevi. Nat Genet, 2003, 33(1):19-20. [16] Dong J, Phelps RG, Qiao R, et al. BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res, 2003, 63(14):3883-3885. 通讯作者: