国际皮肤性病学杂志    2004 30 (3): 167-169   ISSN: 2096-5540  CN: 32-1880/R   紫外线引起氧化应激与细胞凋亡机制研究进展 闫言, 王宝玺 中国医学科学院、中国协和医科大学北京协和医院皮肤科 北京 100730 收稿日期 2003-07-24  修回日期 null  网络版发布日期 null 参考文献  [1] Darr D, Fridovich I. Free radicals in cutaneous biology. J Invest Dermatol, 1994, 102:671-675. [2] Peus D, Vasa RA, Meves A, et al. H2O2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes.J Invest Dermatol, 1998, 110:966-971. [3] Podhaisky HP, Riemschneider S, Wohlrab W. UV light and oxidative damage of the skin. Pharmazie, 2002, 57:30-33. [4] Miyachi Y, Horio T, Imamura S. Sunburn cell formation is prevented by scavenging oxygen intermediates. Clin Exp Dermatol, 1983, 8:305-310. [5] Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med, 1997, 3:614-20. [6] Ouhtit A, Muller HK, Davis DW, et al. Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol, 2000, 156:201-207. [7] Kastan MB, Onyekwere O, Sidransky D, et al. Participation of p53 protein in the cellular response to DNA damage. Cancer Res, 1991,51:6304-6311. [8] Neades R, Cox L, Pelling JC. S-phase arrest in mouse keratinocytes exposed to multiple doses of ultraviolet B/A radiation. Mol Carcinog,1998, 23:159-167. [9] Ahn KS, Park KS, Jung KM, et al. Inhibitory effect of glycolic acid on ultraviolet B-induced c-fos expression, AP-1 activation and p53-p21 response in a human keratinocyte cell line. Cancer Lett, 2002,186:125-135. [10] Seo SJ, Choi HG, Chung HJ, et al. Time course of expression of mRNA of inducible nitric oxide synthase and generation of nitric oxide by ultraviolet B in keratinocyte cell lines. Br J Dermatol, 2002, 147:655-662. [11] Weller R, Billiar T, Vodovotz Y. Pro-and anti-apoptotic effects of nitric oxide in irradiated keratinocytes: the role of superoxide. Skin Pharmacol Appl Skin Physiol, 2002, 15:348-352. [12] Flohe L, Brigelius-Flohe R, Saliou C, et al. Redox regulation of NFkappa B activation. Free Radic Biol Med, 1997, 22:1115-1126. [13] Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J, 1996, 10:709-720. [14] Grimm S, Baeuerle PA. The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits. Biochem J,1993, 290:297-308. [15] Brown K, Park S, Kanno T,et al. Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A, 1993, 90:2532-2536. [16] Scovassi Al, Poirier GG. Poly(ADP-ribosylation) and apoptosis. Mol Cell Biochem, 1999, 199:125-137. [17] Chang H, Sander CS, Muller CS, et al. Detection of poly(ADP-ribose) by immunocytochemistry: a sensitive new method for the early identification of UVB-and H2O2-induced apoptosis io keratinocytes.Biol Chem, 2002, 383:703-708. [18] Virag L, Szabo E, Bakondi E. et al. Nitric oxide-peroxynitrite-poly (ADP-ribose) polymerase pathway in the skin. Exp Dermatol, 2002,11:189-202. 通讯作者: