国际皮肤性病学杂志    2004 30 (1): 54-56   ISSN: 2096-5540  CN: 32-1880/R   真菌耐药机制研究现状 李筱芳, 吕昭萍 昆明医学院第一附属医院皮肤科 650032 收稿日期 2002-12-24  修回日期 null  网络版发布日期 null 参考文献  [1] Kontoyiannis DP,Lewis RE.Antifungal drug resistance of pathogenic fungi.Lancet,2002,359(9312):1135-1144. [2] vanden Bossche H,Marichal P,Odds FC,et al.Characterization of an azole-resistant Candida glabrata isolate.Antimicrob Agents Chemother,1992,36(12):9602-2610. [3] Ghannoum MA,Rice LB.Antifungal agents:mode of action,mechanisms of resistance,and correlation of these mechanisms with bacterial resistance.Clin Microbiol Rev,1999,12(4):501-517. [4] White TC,Marr KA,Bowden RA.Clinical,cellular,and molecular factors that contribute to antifungal drug resistance.Clin Microbiol Rev,1998,11(2):382-409. [5] Kakeya H,Miyazaki Y,Miyazaki H,et al.Genetic analysis of azole resistance in the Darlington strain of Candida albicans.Antimicrob Agents Chemother,9000,44(11):2985-2990. [6] Kohli A,Smriti,Mukhopadhyay K,et al.In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry.Antimicrob Agents Chemother,2002,46(4):1046-1052. [7] Emter R,Heese-Peck A,Kralli A.ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms.FEBS Lett,2002,591(1-3):57-61. [8] Akache B,Turcotte B.New regulators of drug sensitivity in the family of yeast zinc cluster proteins.J Biol Chem,2002,277(24):21254-21260. [9] Hellauer K,Akache B,MacPherson S,et al.Zinc cluster protein Rdrl p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter.J Biol Chem,2002,277(20):17671-17676. [10] St Georgiev V.Membrane transporters and antifungal drug resistance.Curr Drug Targets,2000,1(3):261-284. [11] Sanglard D,Iseher F,Monod M,et al.Cloning of Candida albicans genes conferring resistance to azole antifungal agents:characterization of CDR2,a new multidrug ABC transporter gene.Microbiology,1997,143(Pt 2):405-4-16. [12] de Mieheli M,Bille J,Schueller C,et al.A common drug-responsive element mediates the upregulation of the Candida albieans ABC transporters CDR1 and CDR2,two genes involved in antifungal drug resistance.Mol Mierobiol,2002,43(5):1197-1214. [13] Sanglard D,Ischer F,Bille J.Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.Antimicrob Agents Chemother.2001,45(4):1174-1183. [14] Katiyar SK,Edlind TD.Identification and expression of multidrug resistance-related ABC transporter genes in Candida krusei.Med Mycol,2001,39(1):109-116. [15] Perea S,Lopez-Ribot JL,Wickes BL,et al.Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.Antimicrob Agents Chemother,2002,46(6):1695-1703. [16] Sanglard D,Ischer F,Monod M,et al.Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors.Antimicrob Agents Chemother,1996,40(10):2300-2305. [17] Wirsching S,Moran GP,Sullivan DJ,et al.MDRI-mediated drug resistance in Candida dubliniensis.Antimicrob Agents Chemother,2001,45(12):3416-3421. [18] De Backer MD,llyina T,Ma XJ,et al.Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray.Antimierob Agents Chemother,2001,45(6):1660-1670. [19] Perea S,Lopez-Ribot JL,Kirkpatrick WR,et al.Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.Antimicrob Agents Chemother,2001,45(10):2676-2684. [20] White TC.Increased mRNA levels of ERG16,CDR,and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus.Antimicrob Agents Chemother,1997,41(7):1482-1487. [21] Kurtz MB,Douglas CM.Lipopeptide inhibitors of fungal glucan synthase.J Med Vet Mycol,1997,35(2):79-86. 通讯作者: