国际皮肤性病学杂志    2004 30 (1): 48-50   ISSN: 2096-5540  CN: 32-1880/R   环氧合酶-2在皮肤肿瘤中的研究进展 刘晓艳, 阮黎明 浙江大学医学院附属第一医院皮肤科 杭州 310003 收稿日期 2003-04-07  修回日期 null  网络版发布日期 null 参考文献  [1] Morita I,Schindler M,Regier MK,et al.Different intracellular locations for prostaglandin endoperoxide H synthase-1 and-2.J Biol Chem,1995,270(18):10902-10908. [2] Garcia-Rodriguez LA,Huerta-Alvarez C.Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs.Epidemiology,2001,12(1):88-93. [3] Eli Y,Przedecki F,Levin G,et al.Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo.Biochem Pharmacol,2001,61(5):565-571. [4] Tsujii M,DuBois RN.Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prustaglandin endoperoxide synthase 2.Cell,1995,83(3):493-501. [5] Marnett LJ.Aspirin and the potential role of prostaglandins in colon cancer.Cancer Res,1992,52(20):5575-5589. [6] Uefuji K,Ichikura T,Mochizuki H.Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer.Clin Cancer Res,2000,6(1):135-138. [7] Tsujii M,Kawano S,Tsuji S,et al.Cyclooxygenase regulates angiogenesis induced by colon cancer cells.Cell,1998,93(5):705-716. [8] Masferrer.JL,Leahy KM,Koki AT,et al.Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.Cancer Res,2000,60(5):1306-1311. [9] Fosslien E.Molecular pathology of cyclooxygenase-2 in neoplasia.Ann Clin Lab Sci,2000,30(1):3-21. [10] Muller-Decker K,Reinerth G,Krieg P,et al.Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin.Int J Cancer,1999,82(5):648-656. [11] Kagoura M,Toyoda M,Matsui C,et al.Immunohistochemical expression of cyclooxygenase-2 in skin cancers.J Cutan Pathol,2001,28(6):298-302. [12] Vogt T,McClelland M,Jung B,et al.Progression and NSAID-induced apoptosis in malignant melanomas are independent of cyclooxygenase II.Melanoma Res,2001,11(6):587-599. [13] Athar M,An KP,Morel KD,et al.Ultraviolet B(UVB)-induced cox-2 expression in murine skin:an immunohistochemical study.Bio-chem Biophys Res Commun,2001,280(4):1042-1047. [14] Pentland AP,Schoggins JW,Scott GA,et al.Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition.Carcinogenesis,1999,20(10):1939-1944. [15] Fischer SM,Lo HH,Gordon GB,et al.Chemopreventive activity of celecoxib,a specific cyclooxygenase-2 inhibitor,and indomethacin against ultraviolet light-induced skin earcinogenesis.Mol Careinog,1999,25(4):231-240. [16] Kim Y,Fischer SM.Transcriptional regulation of cyclooxygenase-2in mouse skin carcinoma cells.Regulatory role of CCAAT/enhancerbinding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues.J Biol Chem,1998,273(42):27686-27694. [17] Chen W,Tang Q,Gonzales MS,et al.Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes.Oncogene,2001,20(29):3921-3926. [18] Thompson EJ,Gupta A,Vielhauer GA,et al.The growth of malignant keratinocytes depends on signaling through the PGE(2)receptor EP1.Neoplasia,2001,3(5):402-410. [19] Marks F,Furstenberger G.Cancer chemoprevention through interruption of multistage carcinogenesis.The lessons learnt by comparing mouse skin carcinogenesis and human large bowel cancer.Eur J Cancer,2000,36(3):314-329. [20] Higashi Y,Kanekura T,Kanzaki T.Enhanced expression of cyclooxygenase(COX)-2 in human skin epidermal cancer cells:evidence for growth suppression by inhibiting COX-2 expression.Int J Cancer,2000,86(5):667-671. 通讯作者: