国际皮肤性病学杂志    2004 30 (1): 16-19   ISSN: 2096-5540  CN: 32-1880/R  

反义核酸技术及其在皮肤科的应用
康尔恂, 郑家润
中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042
收稿日期 2003-04-08  修回日期 null  网络版发布日期 null
参考文献  [1] Yacyshyn BR,Crooke ST.The concept and application of antisense oligonucleotides.Dis Colon Rectum,2001,44(9):1241-1243.
[2] White PJ,Fogarty RD,MeKean SC,et al.Oligonucleotide uptake in cultured keratinocytes:influence of confluence,cationic liposomes,and keratinocyte cell type.J Invest Dermatol,1999,112(5):699-705.
[3] van Erp PE,Wingens M.Does antisense make sense in dermatology?Acta Derm Venereol,2001,81(6):385-391.
[4] Fimmel S,Saborowski A,Offanos CE,et al.Development of efficient transient transfection systems for introducing antisense oligonucleotides into human epithelial skin cells.Horm Res,2000,54(5-6):306-311.
[5] Liu C,Qureshi IA,Ding X,et al.Modulation of multidrug resistance gene(mdr-1)with antisense oligodeoxynucleotides.Clin Sci(Lond),1996,91(1):93-98.
[6] Nestle FO,Mitra RS,Bennett CF,et al.Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes.J Invest Dermatol,1994,103(4):569-575.
[7] Hertl M,Neckers LM,Katz SI.Inhibition of interferon-gamma-indueed intercellular adhesion molecule-1 expression on human keratinocytes by phosphorothioate antisense oligodeoxynucleotides is the consequence of antisense-specific and antisense-non-speeific effects.J Invest Dermatol,1995,104(5):813-818.
[8] Yamakawa H,Abe T,Saito T,et al.Properties of nicked and circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligodeoxynucleotides.Bioorg Med Chem,1998,6(7):1025-1032.
[9] White PJ,Fogarty RD,Liepe IJ,et al.Live eonfocal microscopy of oligonueleotide uptake by kerafinocytes in human skin grafts on nude mice.J Invest Dermatol,1999,112(6):887-892.
[10] White PJ,Gray AC,Fogarty RD,et al.C-5 propyne-modified oligonueleotides penetrate the epidermis in psoriatic and not normal human skin after topical application.J Invest Dermatol,2002,118(6):1003-1007.
[11] Mehta RC,Stecker KK,Cooper SR,et al.Intercellular adhesion molecule-1 suppression in skin by topical delively of anti-sense oligonucleotides.J Invest Dermatol,2000,115(5):805-812
[12] Wake N.Application of antisense oligonueleotides into treatment of human cervical carcinoma.Nippon Sanka Fujinka Gakkai Za shi,1994,46(8):742-748.
[13] Haydock PV,Blomquist C,Brumbaugh S,et al.Antisense prolilaggrin RNA delays and decreases profilaggrin expression and alters in vitro differentiation of rat epidermal keratinoeytes.J Invest Dermatol,1993,101(2):118-126.
[14] Sewell KL,Geary RS,Baker BF,et al.Phase I trial of ISIS 104838,a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha.J Pharmacol Exp Ther,2002,303(3):1334-1343.
[15] Gewirtz AT,Sitaraman S.Alicaforsen.Isis Pharmaceuticals.Curt Opin Investig Drugs,2001,2(10):1401-1406.
[16] Wraight CJ,White PJ,McKean SC,et al.Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonueleotides.Nat Biotechnol,2000,18(5):521-526.
[17] Smyth AP,Rook SL,Detmar M,et al.Antisense oligonucleotides inhibit vascular endothelial growth factor/vascular permeability factor expression in normal human epidermal keratinocytes.J Invest Dermatol,1997,108(4):523-526.

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