国际皮肤性病学杂志    2003 29 (5): 291-293   ISSN: 2096-5540  CN: 32-1880/R   B淋巴细胞刺激物与系统性红斑狼疮的研究进展 李东升, 李家文 华中科技大学同济医学院附属协和医院皮肤科 武汉 430022 收稿日期 2002-11-12  修回日期 null  网络版发布日期 null 参考文献  [1] Moore PA,Belvedere O,Orr A,et al.BLyS:member of the tumor necrosis factor family and B lymphocyte stimulator.Science,1999,285(5425):260-263. [2] Schneider P,MacKay F,Steiner V,et al.BAFF,a novel ligand of the tumor necrosis factor family,stimulates B cell growth.J Exp Med,1999,189(11):1747-1756. [3] Shu HB,Hu WH,Johnson H.TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.J Leukoc Biol,1999,65(5):680-683. [4] Mukhopadhyay A,Ni J,Zhai Y,et al.Identification and characterization of a novel cytokine,THANK,a TNF homologue that activates apoptosis,nuclear factor-kappaB,and c-Jun NH2-terminal kinase.J Biol Chem,1999,274(23):15978-15981. [5] Nardelli B,Belvedere O,Roschke V,et al.Synthesis and release of B-lymphocyte stimulator from myeloid cells.Blood,2001,97(1):198-204. [6] Gross JA,Johnston J,Mudri S,et al.TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.Nature,2000,404(6781):995-999. [7] Thompson JS,Bixler SA,Qian F,et al.BAFF-R,a newly identified TNF receptor that specifically interacts with BAFF.Science,2001,293(5537):2108-2111. [8] Wang H,Marsters SA,Baker T,et al.TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice.Nat Immunol,2001,2(7):632-637. [9] Mackay F,Woodcock SA,Lawton P,et al.Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.J Exp Med,1999,190(11):1697-1710. [10] Khare SD,Sarosi I,Xia XZ,et al.Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.Proc Natl Acad Sci U S A,2000,97(7):3370-3375. [11] Yu G,Boone T,Delaney J,et al.APRIL and TALL-I and receptors BCMA and TACI:system for regulating humoral immunity.Nat Immunol,2000,1(3):252-256. [12] Stohl W.Systemic lupus erythematosus:a blissless disease of too much BLyS(B lymphocyte stimulator) protein.Curr Opin Rheumatol,2002,14(5):522-528. [13] Yan M,Brady JR,Chan B,et al.Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.Curr Biol,2001,11(19):1547-1552. [14] Yan M,Wang H,Chan B,et al.Activation and accumulation of B cells in TACI-deficient mice.Nat Immunol,2001,2(7):638-643. [15] Schiemann B,Gommerman JL,Vora K,et al.An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.Science,2001,293(5537):2111-2114. [16] Llorente L,Richaud-Patin Y,Wijdenes J,et al.Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus.Eur Cytokine Netw,1993,4(6):421-427. [17] Viallard JF,Pellegrin JL,Ranchin V,et al.Th1(IL-2,interferon-gamma(IFN-gamma)) and Th2(IL-10,IL-4) cytokine production by peripheral blood mononuclear cells(PBMC) from patients with systemic lupus erythematosus(SLE).Clin Exp Immunol,1999,115(1):189-195. [18] Hagiwara E,Gourley MF,Lee S,et al.Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood.Arthritis Rheum,1996,39(3):379-385. [19] Miret C,Font J,Molina R,et al.Relationship of oncogenes(sFas,Bcl-2) and cytokines(IL-10,alfa-TNF) with the activity of systemic lupus erythematosus.Anticancer Res,2001,21(4B):3053-3059. [20] Gescuk BD,Davis JC Jr.Novel therapeutic agents for systemic lupus erythematosus.Curr Opin Rheumatol,2002,14(5):515-521. 通讯作者: