国际皮肤性病学杂志    2003 29 (5): 288-290   ISSN: 2096-5540  CN: 32-1880/R   白介素在银屑病发病机制中的研究新进展 姜海燕, 方栩 复旦大学医学院华山医院皮肤科 上海 200040 收稿日期 2002-11-28  修回日期 null  网络版发布日期 null 参考文献  [1] Wei L,Debets R,Hegmans JJ,et al.IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system.IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production.J Pathol,1999,187(3):358-364. [2] el Barnawi NY,Giasuddin AS,Ziu MM,et al.Serum cytokine levels in psoriasis vulgaris.Br J Biomed Sci,2001,58(1):40-44. [3] Schon M,Behmenburg C,Denzer D,et al.Pathogenic function of IL-1 beta in psoriasiform skin lesions of flaky skin(fsn/fsn) mice.Clin Exp Immunol,2001,123(3):505-510. [4] Nishibu A,Han GW,Iwatsuki K,et al.Overexpression of monocyte-derived cytokines in active psoriasis:a relation to coexistent arthropathy.J Dermatol Sci,1999,21(1):63-70. [5] Duan H,Koga T,Kohda F,et al.Interleukin-8-positive neutrophils in psoriasis.J Dermatol Sci,2001,26(2):119-124. [6] Szepietowski J,Walker C,Hunter JA,et al.Elevated leukaemia inhibitory factor(LIF) expression in lesional psoriatic skin:correlation with interleukin(IL)-8 expression.J Dermatol,2001,28(3):115-122. [7] Asadullah K,Docke WD,Ebeling M,et al.Interleukin 10 treatment of psoriasis:clinical results of a phase 2 trial.Arch Dermatol,1999,135(2):187-192. [8] Asadullah K,Friedrich M,Hanneken S,et al.Effects of systemic interleukin-10 therapy on psoriatic skin lesions:histologic,immunohistologic,and molecular biology findings.J Invest Dermatol,2001,116(5):721-727. [9] Reich K,Garbe C,Blaschke V,et al.Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation,downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation.J Invest Dermatol,2001,116(2):319-329. [10] Trepicchio WL,Ozawa M,Walters IB,et al.Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions.J Clin Invest,1999,104(11):1527-1537. [11] Bozza M,Bliss JL,Dorner AJ,et al.Interleukin-11 modulates Th1/Th2 cytokine production from activated CD4+ T cells.J Interferon Cytokine Res,2001,21(1):21-30. [12] Hong K,Chu A,Ludviksson BR,et al.IL-12,independently of IFN-gamma,plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder.J Immunol,1999,162(12):7480-7491. [13] Hong K,Berg EL,Ehrhardt RO.Persistence of pathogenic CD4+ Th1-like cells in vivo in the absence of IL-12 but in the presence of autoantigen.J Immunol,2001,166(7):4765-4772. [14] Ruckert R,Asadullah K,Seifert M,et al.Inhibition of keratinocyte apoptosis by IL-15:a new parameter in the pathogenesis of psoriasis? J Immunol,2000,165(4):2240-2250. [15] Ohta Y,Hamada Y,Katsuoka K.Expression of IL-18 in psoriasis.Arch Dermatol Res,2001,293(7):334-342. [16] Takeda K,Tsutsui H,Yoshimoto T,et al.Defective NK cell activity and Th1 response in IL-18-deficient mice.Immunity,1998,8(3):383-390. [17] Rich BE,Kupper TS.Cytokines:IL-20-a new effector in skin inflammation.Curr Biol,2001,11(13):R531-534. 通讯作者: