国际皮肤性病学杂志    2003 29 (4): 256-258   ISSN: 2096-5540  CN: 32-1880/R   Rb基因与HPV相关肿瘤 陈小强, 涂亚庭 华中科技大学同济医学院协和医院皮肤科 武汉 430022 收稿日期 2002-05-28  修回日期 null  网络版发布日期 null 参考文献  [1] Smith RC,Wills KN,Antelman D,et al.Adenoviral constructs encoding phosphorylation-competent full-length and truncated forms of the human retinoblastoma protein inhibit myocyte proliferation and neointima formation.Circulation,1997,96(6):1899-1905. [2] Nishinaka T,Fu YH,Chen LI,et al.A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product,RB,and transcription factor SP1.Biochim Biophys Acta,1997,1351(3):274-286. [3] Fang X,Jin X,Xu HJ,et al.Expression of p16 induces transcriptional downregulation of the RB gene.Oncogene,1998,16(1):1-8. [4] Ishiji T.Molecular mechanism of carcinogenesis by human papillomavirus-16.J Dermatol,2000,27(2):73-86. [5] Cooper K,Herrington CS,Stickland JE,et al.Episomal and integrated human papillomavirus in cervical neoplasia shown by non-isotopic in situ hybridisation.J Clin Pathol,1991,44(12):990-996. [6] Wang P,Peng ZL,Wang H,et al.Study on the carcinogenic mechanism of human papilomavirus typel6 E7 protein in cervical carcinoma.J Exp Clin Virol,2000,14(2):117-120. [7] Boyer SN,Wazer DE,Band V.E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.Cancer Res,1996,56(20):4620-4624. [8] Alunni-Fabbroni M,Littlewood T,Deleu L,et al.Induction of S phase and apoptosis by the human papillomavirus type 16 E7 protein are separable events in immortalized rodent fibroblasts.Oncogene,2000,19(19):2277-2285. [9] Giarre M,Caldeira S,Malanchi I,et al.Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle Arrest.J Virol,2001,75(10):4705-4712. [10] Milde-Langosch K,Riethdorf S,Kraus-Poppinghaus A,et al.Expressioo of cyclin-dependent kinase inhibitors p16MTS1,p21WAF1,and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas.Virchows Arch,2001,439(1):55-61. [11] Choo KB,Chong KY.Absence of mutation in the p53 and the retinoblastoma susceptibility genes in primary cervical carcinomas.Virology,1993,193(2):1042-1046. [12] Zhao W,Yu X,Zhou Y,et al.Rb gene and HpV-16 E7 oncogene in cervical squamous cell carcinoma.Acta Acad Med SHAN DoNG,1997,35:290-293. [13] Kim JW,Lee CG,Han SM,et al.Loss of heterozygosity of the retinoblastoma and p53 genes in primary cervical carcinomas with human papillomavirus infection.Gynecol Oncol,1997,67(2):215-221. [14] Mathevet P,Frappart L,Hittelman W.Cervix dysplasias:study of Rb and p53 gene expression and correlation with mitotic activity.Gynecol Obstet Fertil,2000,28(1):44-50. [15] Arany I,Rady P,Tyring SK.Alterations in cytokine/antioncogene expression in skin lesions caused by "low-risk" types of human papillomaviruses.Viral Immunol,1993,6(4):255-265. [16] Schell BJ,Rosen T,Rady P,et al.Verrucous carcinoma of the foot associated with human papillomavirus type 16.J Am Acad Dermatol,2001,45(1):49-55. [17] Andl T,Kahn T,Pfuhl A,et al.Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.Cancer Res,1998,58(1):5-13. [18] Gupta D,Holden J,Layfield L.Topoisomerase alpha Ⅱ,retinoblastoma gene product,and p53:potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis.Appl Immunohistochem Mol Morphol,2001,9(1):86-91. 通讯作者: