国际皮肤性病学杂志    2003 29 (4): 209-212   ISSN: 2096-5540  CN: 32-1880/R   细胞因子与新生隐球菌感染 黄欣, 温海 第二军医大学长征医院皮肤科 上海 200003 收稿日期 2002-09-26  修回日期 null  网络版发布日期 null 参考文献  [1] Li RK,Mitchell TG.Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C.neoformans antiserum.J Med Vet Mycol,1997,35(5):327-334. [2] Barluzzi R,Brozzetti A,Mariucci G,et al.Establishment of protective immunity against cerebral cryptococcosis by means of an avirulent,non-melanogenic Cryptococcus neoformans strain.J Neuroimmunol,2000,109(2):75-86. [3] Kawakami K,Hossain Qureshi M,Zhang T,et al.Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines.Cell Immunol,1999,197(1):55-61. [4] Chaka W,Heyderman R,Gangaidzo I,et al.Cytokine profiles in cerebrospinal fluid of human immunodeficiency virus-infected patients with cryptococcal meningitis:no leukocytosis despite high interleukin-8 levels.J Infect Dis,1997,176(6):1633-1636. [5] Retini C,Kozel TR,Pietrella D,et al.Interdependency of interleukin-10 and interleukin-12 in regulation of T-cell differentiation and effector function of monocytes in response to stimulation with Cryptococcus neoformans.Infect Immun,2001,69(10):6064-6073. [6] Clemons KV,Brummer E,Stevens DA.Cytokine treatment of central nervous system infection:efficacy of intedeukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis.Antimicrob Agents Chemother,1994,38(3):460-464. [7] Parayath KE,Harrison TS,Levitz SM.Effect of intedeukin(IL)-15 priming on IL-12 and interferon-gamma production by pathogen-stimulated peripheral blood mononuclear cells from human immunodeficiency virus-seropositive and-seronegative donors.J Infect Dis,2000,181(2):733-736. [8] Zhang T,Kawakami K,Qureshi MH,et al.Intedeukin-12(IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells.Infect Immun,1997,65(9):3594-3599. [9] Walenkamp AM,Chaka WS,Verheul AF,et al.Cryptococcus neoformans and its cell wall components induce similar cytokine profiles in human peripheral blood mononuclear cells despite differences in structure.FEMS Immunol Med Microbiol,1999,26(3-4):309-318. [10] Pietrella D,Cherniak R,Strappini C,et al.Role of mannoprotein in induction and regulation of immunity to Cryptococcus neoformans.Infect Immun,2001,69(5):2808-2814. [11] Clemons KV,Lutz JE,Stevens DA.Efficacy of recombinant gamma interferon for treatment of systemic cryptococcosis in SCID mice.Antimicrob Agents Chemother,2001,45(3):686-689. [12] Buchanan KL,Doyle HA.Requirement for CD4(+) T lymphocytes in host resistance against Cryptococcus neoformans in the central nervous system of immunized mice.Infect Immun,2000,68(2):456-462. [13] Murphy JW,Zhou A,Wong SC.Direct interactions of human natural killer cells with Cryptococcus neoformans inhibit granulocyte-macrophage colony-stimulating factor and tumor necrosis factor alpha production.Infect Immun,1997,65(11):4564-4571. [14] Vecchiarelli A,Retini C,Pietrella D,et al.Downregulation by cryptococcal polysaccharide of tunor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.Infect Immun,1995,63(8):2919-2923. [15] Lortholary O,Improvisi L,Rayhane N,et al.Cytokine profiles of AIDS patients are similar to those of mice with disseminated Cryptococcus neoformans infection.Infect Immun,1999,67(12):6314-6320. [16] Kawakami K,Qureshi MH,Koguchi Y,et al.Role of TNF-alpha in the induction of fungicidal activity of mouse peritoneal exudate cells against Cryptococcus neoformans by IL-12 and IL-18.Cell Immunol,1999,193(1):9-16. [17] Aguirre KM,Gibson GW.Differing requirement for inducible nitric oxide synthase activity in clearance of primary and secondary Cryptococcus neoformans infection.Med Mycol,2000,38(5):343-353. [18] Rayhane N,Lortholary O,Fitting C,et al.Enhanced sensitivity of tumor necrosis factor/lymphotoxin-alpha-deficient mice to Cryptococcus neoformans infection despite increased levels of nitrite/nitrate,interferon-gamma,and interleukin-12.J Infect Dis,1999,180(5):1637-1647. [19] Barluzzi R,Brozzetti A,Delfino D,et al.Role of the capsule in microglial cell-Cryptococcus neoformans interaction:impairment of antifungal activity but not of secretory functions.Med Mycol,1998,36(4):189-197. [20] Jones TC.The effect of granulocyte-macrophage colony stimulating factor(rGM-CSF) on macrophage function in microbial disease.Med Oncol,1996,13(3):141-147. [21] Vecchiarelli A,Monari C,Baldelli F,et al.Beneficial effect of recombinant human granulocyte colony-stimulating factor on fungicidal activity of polymorphonuclear leukocytes from patients with AIDS.J Infect Dis,1995,171(6):1448-1454. [22] Nassar F,Brummer E,Stevens DA.Effect of in vivo macrophage colony-stimulating factor on fungistasis of bronchoalveolar and peritoneal macrophages against Cryptococcus neoformans.Antimicrob Agents Chemother,1994,38(9):2162-2164. [23] Graybill JR,Bocanegra R,Lambros C,et al.Granulocyte colony stimulating factor therapy of experimental cryptococcal meningitis.J Med Vet Mycol,1997,35(4):243-247. 通讯作者: