国际皮肤性病学杂志    2003 29 (2): 88-91   ISSN: 2096-5540  CN: 32-1880/R   DNA-抗DNA免疫复合物在系统性红斑狼疮发病中的作用 尹若菲, 曾凡钦 中山大学孙逸仙纪念医院皮肤科, 广州510120 收稿日期 2002-06-13  修回日期 null  网络版发布日期 null 参考文献  [1] Bodi I, Varadi P, Pokorny G,et al. Polyneuropathy with endoneurial immune complex deposition as the first manifestation of systemic lupus erythematosus. Acta Neuropathol (Berl), 1998, 96(3):297-300. [2] Vizjak A, Perkovic T, Rozman B,et al. Skeletal muscle immune de posits in systemic lupus erythematosus. Correlation with histologic changes, autoantibodies, and clinical involvement. Scand J Rheumatol, 1998, 27(3):207-214. [3] Hylkema MN, van Bruggen MC, ten Hove T, et al. Histone-contai ning immune complexes are to a large extent responsible for anti-dsDNA reactivity in the Farr assay of active SLE patients. J Autoimmun,2000, 14(2):159-168. [4] Nezlin R. A quantitative approach to the determination of antigen in immune complexes. J Immunol Methods, 2000, 237 (1-2):1-17. [5] Bengtsson A, Nezlin R, Shoenfeld Y,et al. DNA levels in circulating immune complexes decrease at severe SLE flares-correlation with complement component C 1 q. J Autoimmun, 1999, 13 (1):111-119. [6] Kitamura H, Shindo K, Sasabe M, et al. Conformational change of DNA on the formation of DNA-anti-DNA antibody immune complex.Nucleic Acids Symp Ser, 1997, (37):145-146. [7] Sato Y, Miyata M, Sato Y, et al. CpG motif-containing DNA frag ments from sera of patients with systemic lupus erythematosus proliferate mononuclear ceils in vitro. J Rheumatol, 1999, 26 (2):294-301. [8] Amoura Z, Koutouzov S, Piette JC. The role of nucleosomes in lupus. Curr Opin Rheumatol, 2000, 12 (5):369-373. [9] van Bruggen MC, Kramers C, Walgreen B, et al. Nucleosomes and histories are present in glomerular deposits in human lupus nephritis. Nephrol Dial Transplant, 1997, 2 (1):57-66. [10] Bernstein KA, Valerio RD, Lefkowith JB. Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/ type IV collagen complex. J Immunol, 1995, 154(5):2424-2433. [11] Di Valerio R, Bernstein KA, Varghese E, et al. Murine lupus glo merulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism. J Immunol, 1995, 155 (4):2258-2268. [12] Madaio MP, Shlomchik MJ. Emerging concepts regarding B cells and autoantibodies in murine lupus nephritis. B cells have multiple roles; all autontibodies are not equal. J Am Soc Nephrol, 1996, 7 (3):387-396. [13] Lefkowith JB, Gilkeson GS. Nephritogenic autoantibodies in lupus:current concepts and continuing controversies. Arthritis Rheum, 1996, 39(6):894-903. [14] Braun N, Risler T. lmmunoadsorption as a tool for the immunomodu lation of the humoral and cellular immune system in autoimmune disease. Ther Apher, 1999, 3(3):240-245. [15] Braun N, Erley C, Klein R,et al. Immunoadsorption onto protein A induces remission in severe systemic lupus erythematosus. Nephrol Dial Transplant, 2000, 15(9):1367-1372. [16] Hiepe F, Pfuller B, Wolbart K,et al. Clq:a multifunctional ligandfor a new immunoadsorption treatment. Ther Apher, 1999, 3 (3):246-251. [17] Suzuki K. The role of immunoadsorption using dextran-sulfate cellu lose columns in the treatment of systemic lupus erythematosus. Ther Apher, 2000, 4(3):239-243. [18] Gaubitz M, Seidel M, Kummer S, et al. Prospective randomized trial of two different immunoadsorbers in severe systemic lupus erythematosus. J Autoimmun, 1998, 11 (5):495-501. 通讯作者: