国际皮肤性病学杂志    2003 29 (2): 82-85   ISSN: 2096-5540  CN: 32-1880/R   核因子-κB与银屑病的研究进展 聂本勇, 郑茂荣, 范清源 第二军医大学长海医院皮肤科, 上海200433 收稿日期 2002-04-22  修回日期 null  网络版发布日期 null 参考文献  [1] Chen F, Castranova V, Shi X, et al. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem, 1999, 45(1):7-17. [2] Robert C, Kupper TS. Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med, 1999, 341 (24):1817-1828. [3] Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest, 2001, 107(2):135-142. [4] Tak PP, Firestein GS. NF-kappaB:a key role in inflammatory diseases. J Clin Invest, 2001, 107 (1):7-11. [5] Foo SY, Nolan GP. NF-kappaB to the rescue:RELs, apoptosis and cellular transformation. Trends Genet, 1999, 15 (6):229-235. [6] Rodriguez MS, Thompson J, Hay RT, et al. Nuclear retention of Ikap paBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem, 1999. 274 (13):9108-9115. [7] Hu Y, Baud V, Delhase M, et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB ki nase. Science, 1999, 284(5412):316-320. [8] Hu Y, Baud V, Oga T, et al. IKKalpha controls formation of the epi dermis independently of NF-kappaB. Nature, 2001, 410(6829):710-714. [9] Murphy JE, Robert C, Kupper TS. Interleukin-1 and cutaneous in flammation:a crucial link between innate and acquired immunity. J Invest Dermatol, 2000, 114 (3):602-608. [10] Freedberg IM, Tomic-Canic M, Komine M, et al. Keratins and the ke ratinocyte activation cycle. J Invest Dermatol, 2001, 116 (5):633-640. [11] Karin M. The beginning of the end:IkappaB kinase (IKK) and NF kappaB activation. J Biol Chem, 1999, 274 (39):27339-27342. [12] Hawiger J. Innate immunity and inflammation:a transcriptional para digm. Immunol Res, 2001,23(2-3):99-109. [13] Kwon YW, Jang ER, Lee YM, et al. Insulin-like growth factor Ⅱ induces interleukin-6 expression via NFkappaB activation in psoriasis. Biochem Biophys Res Commun, 2000, 278 (2):312-317. [14] Aragane Y, Yamada H, Schwarz A, et al. Transforming growth factor alpha induces interleukin-6 in the human keratinocyte cell line HaCaT mainly by transcriptional activation. J Invest Dermatol, 1996, 106(6):1192-1197. [15] Klement JF, Rice NR, Car BD, et al. IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Mol Cell Biol, 1996, 16(5):2341-2349. [16] Chen CL, Singh N, Yull FE,et al. Lymphocytes lacking I kappa B-al pha develop normally, but have selective defects in proliferation and function. J Immunol, 2000,165 (10):5418-5427. [17] Kaufman CK, Fuchs E. It's got you covered. NF-kappaB in the epidermis. J Cell Biol, 2000, 149(5):999-1004. [18] Chen CL, Yull FE, Cardwell N, et al. RAG2-/-, I kappa B-alpha-/chimeras display a psoriasiform skin disease. J Invest Dermatol, 2000, 115(6):1124-1133. [19] Aronica MA, Mora AL, Mitchell DB, et al. Preferential role for NFkappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol, 1999, 163(9):5116-5124. [20] Zollner TM, Podda M, Pien C,et al. Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model. J Clin Invest, 2002, 109(5):671-679. [21] Boehncke WH, Zollner TM, Dressel D, et al. Induction of psoriasiform inflammation by a bacterial superantigen in the SCID-hu xenogeneic transplantation model. J Cutan Pathol, 1997, 24(1):1-7. [22] Makris C, Godfrey VL, Krahn-Senftleben G, et al. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathysimilar to the human X-linked disorder incontinentia pigmenti. Mol Cell, 2000, 5(6):969-979. [23] Schmidt-Ullrich R, Aebischer T, Hulsken J, et al. Requirement of NF kappaB/Rel for the development of hair follicles and other epidermal appendices. Development, 2001, 128(19):3843-3853. [24] Chaturvedi V, Qin JZ, Denning MF, et al. Apoptosis in proliferating,senescent, and immortalized keratinocytes. J Biol Chem, 1999, 274 (33):23358-23367. [25] Seitz CS, Freiberg RA, Hinata K, et al. NF-kappaB determines locali zation and features of cell death in epidermis. J Clin Invest, 2000, 105 (3):253-260. 通讯作者: