国际皮肤性病学杂志    2003 29 (1): 25-27   ISSN: 2096-5540  CN: 32-1880/R  

防御素和皮肤病
殷文浩, 郑敏
浙江大学医学院附属第二医院皮肤科, 杭州 310009
收稿日期 2002-04-03  修回日期 null  网络版发布日期 null
参考文献  [1] Ganz T.Defensins and host defense.Science,1999,286(5439);420-421.
[2] Harder J,Bartels J,Christophers E,et al.A peptide antibiotic from human skin.Nature,1997,387(6636);861.
[3] Bals R.Epithelial antimicrobial peptides in host defense against infection.Respir Res,2000,1(3):141-150.
[4] Yang D,Chertov O,Bykovskaia SN,et al.Beta-defensins:linking innate and adaptive immunity through dendritic and T cell CCR6.Science,1999,286(5439);525-528.
[5] Ortega MR,Ganz T,Milner SM.Human beta defensin is absent in burn blister fluid.Burns,2000,26(8);724-726.
[6] Hill CP,Yee J,Selsted ME,et al.Crystal structure of defensin HNP-3,an amphiphilic dimer:mechanisms of membrane permeabilization.Science,1991,251(5000);1481-1485.
[7] Liu L,Wang L,Jia HP,et al.Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.Gene,1998,222(2);237-244.
[8] van Wetering S,Sterk PJ,Rabe KF,et al.Defensins:key players or bystanders in infection,injury,and repair in the lung?.J Allergy Clin Immunol,1999,104(6):1131-1138.
[9] Schroder JM.Epithelial peptide antibiotics.Biochem Pharmacol,1999,57(2);121-134.
[10] Harder J,Bartels J,Christophers E,et al.Isolation and characterization of human beta-defensin-3,a novel human inducible peptide antibiotic.J Biol Chem,200l,276(8);5707-5713.
[11] Jia HP,Schutte BC,Schudy A,et al.Discovery of new human betadefensins using a genomics-based approach.Gene,2001,263(1-2);211-218.
[12] Smith JJ,Travis SM,Greenberg EP,et al.Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.Cell,1996,85(2):229-236.
[13] Ali RS,Falconer A,Ikram M,et al..Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin.J Invest Dermatol,2001,117(1);106-111.
[14] Henseler T,Christophers E.Disease concomitance in psoriasis.J Am Acad Dermatol,1995,32(6);982-986.
[15] Shi RJ,Simpson-Haidaris PJ,Lerner NB,et al.Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection:involvement of the transcription factor NF-kappa B.Infect Immun,1998,66(3);1070-1075.
[16] Sha WC.Regulation of immune responses by NF-kappa B/Rel transcription factor.J Exp Med,1998,187(2);143-146.
[17] Schroder JM,Harder J.Human beta-defensin-2.Int J Biochem Cell Biol,1999,31(6);645-651.
[18] Chronnell CM,Ghali LR,Ali RS,et al.Human beta defensin-1 and-2 expression in human pilosebaceous units:upregulation in acne vulgaris lesions.J Invest Dermatol,2001,117(5):1120-1125.
[19] Schmid P,Grenet O,Medina J,et al.An intrinsic antibiotic mechanism in wounds and tissue-engineered skin.J Invest Dermatol,2001,116(3);471-472.
[20] Milner SM,Ortega MR.Reduced antimicrobial peptide expression in human burn wounds.Burns,1999,25(5);411-413.
[21] Befus AD,Mowat C,Gilchrist M,et al.Neutrophil defensins induce histamine secretion from mast cells:mechanisms of action.J Immunol,1999,163(2):947-953.
[22] Niyonsaba F,Someya A,Hirata M,et al.Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2)production from mast cells.Eur J Immunol,2001,31(4);1066-1075.
[23] Frohm M,Gunne H,Bergman AC,et al.Biochemical and antibacterial analysis of human wound and blister fluid.Eur J Biochem,1996,237(1);86-92.
[24] Nakashima H,Yamamoto N,Masuda M,et al.Defensins inhibit HIV replication in vitro.AIDS,1993,7(8);1129.
[25] Borenstein LA,Ganz T,Sell S,et al.Contribution of rabbit leukocyte defensins to the host response in experimental syphilis.Infect Immun,1991,59(4);1368-1377.

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