国际皮肤性病学杂志    2002 28 (5): 283-284   ISSN: 2096-5540  CN: 32-1880/R   白介素20与银屑病 方立富1, 王刚2 1. 江苏省丰县人民医院皮肤科, 221700; 2. 解放军海军总医院皮肤科 收稿日期 2001-12-15  修回日期 null  网络版发布日期 null 参考文献  [1] Rich BE, Kupper TS. Cytokines;IL-20-a new effector in skin inflammation. Curr Biol, 2001, 11(13):R531-R534. [2] Blumberg H, Conklin D, Xu WF, et al. Interleukin 20;discovery,receptor identification, and role in epidermal function. Cell, 2001,104(1):9-19. [3] Cookson W. The alliance of genes and environment in asthma and allergy. Nature, 1999, 402(6760 Suppl):B5-11. [4] Sano S, Itami S, Takeda K, et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J, 1999, 18(17):4657-4668. [5] O'Farrell AM, Liu Y, Moore KW, et al. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms;evidence for Stat3-dependent and-independent pathways. EMBO J, 1998, 17(4):1006-1018. [6] Kunz M, Henseleit-Walter U, Sorg C, et al. Macrophage marker 27E10 on human keratinocytes helps to differentiate discoid lupus erythematosus and Jessner's lymphocytic infiltration of the skin. Eur J Dermatol, 1999, 9(2):107-110. [7] Volk H, Asadullah K, Gallagher G, et al. IL-10 and its homologs:important immune mediators and emerging immunotherapeutic targets.Trends Immunol, 2001, 22(8):414-417. [8] Gottlieb SL, Gilleaudeau P, Johnson R,et al. Response of psoriasis to a lymphocyte-selective toxin(DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat Med, 1995, 1(5):442-447. [9] Carroll JM, Crompton T, Seery JP, et al. Transgenic mice expressing IFN-gamma in the epidermis have eczema, hair hypopigmentation,and hair loss. J Invest Dermatol,1997, 108(4):412-422. [10] Mosmann TR. Properties and functions of interleukin-10. Adv Immunol, 1994, 56:1-26. [11] Asadullah K, Docke WD, Sabat RV, et al. The treatment of psoriasis with IL-10;rationale and review of the first clinical trials. Expert Opin Investig Drugs, 2000, 9(1):95-102. [12] Seiffert M, Sterry W, Effenberger E, et al. The antipsoriatic activity of IL-10 is rather caused by effects on peripheral blood cells than by a direct effect on human keratinocytes. Arch Dermatol Res, 2000, 292(4):164-172. 通讯作者: