|
国际皮肤性病学杂志 2002 28 (2): 79-81 ISSN: 2096-5540 CN: 32-1880/R |
|
|
|
|
|
重症联合免疫缺陷病发病机制和基因治疗的进展 |
肖生祥, 彭振辉 |
西安交通大学第二医院皮肤科, 700004 |
收稿日期 2001-08-29 修回日期 null 网络版发布日期 null |
参考文献 [1] Freedberg IM,et al.Fitzpatrick's Dermatology in General Medicine.5th ed,New York:McGraw-Hill,1999.1401. [2] Noguchi M,Yi H,Resanblatt HM,et al.Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.Cell,1993,73(1):147-157. [3] Russell SM,Keegan AD,Harada N,et al.Interlenkin-2 receptor gamma chain:a functional component of the interleukin-4 receptor.Science,1993,262(5141):1880-1883. [4] Jameson JL,et al.Principles of Molecular Medicine.1st ed,New York:Humana Press In,1998.249. [5] Santisteban I,Arredondo-Vega FX,Kelly S,et al.Novel splicing,missense,and deletion mutations in seven adenosine deaminase-deficient patients with late/deLayed onset of combined immunedeficiency disease.Contribution of genotype to phenotype.J Clin Invest,1993,92 (5):2291-23O2. [6] Russell SM,Tayebi N,Nakajima H,et al.Mutation of Jak3 in a patient with SCID:essential role of Jak3 in lymphoid development.Science,1995,270(5237):797-800. [7] Puel A,Ziegler SF,Buckley RH,et al.Defective IL7R expression in T (-) B (+) NK (+) severe combined immunedeficiancy.Nat Genet,1998,20(4):394-397. [8] Buckley,RH,Schiff SE,Schiff RI,et al.Hematopoiefic stem-cell trans-plantation for the treatment of severe combined immunodeficiency.N Engl J Med,1999,340(7):508-516. [9] Blaese RM,Culver KW,Miner AD,et al.T lymphocyte-directed gene therapy for ADA-SCID:initial trial results after 4 years.Science,1995,270(5235):475-480. [10] Bordignon C,Notarangelo LD,Nobili N,et al.Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunedeficient patients.Science,1995,270(5235):470-475. [11] Kohn DB,Hershfield MS,Carbonaro D,et al.T lymphocytes with a nor-real ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34 + cells in ADA-deficient SCID neonates.Nat Med,1998,4(7):775-780. [12] Cavazzana-Calvo M,Hacein-Bey S,de Saint Basile G,et al.Gene thera-py of human severe combined immunadeficiency (SCID)-X1 disease.Science,2000,288(5466):669-672. [13] Buckley RH.Gene therapy for human SCID:dreams become reality.Nat Mad,2000,6(6):623-624. [14] Kohn DB.Gene therapy for XSCID:the first success of gene therapy.Pe-diatr Res,2000,48(5):578. [15] Stephenson J.Gene therapy trials show clinical efficacy.JAMA,2000,283(5):589-590. [16] Anderson WF.Gene therapy.The best of times,the worst of times.Science.2000,288(5466):627-629. |
|
|
|
通讯作者: |
|