国际皮肤性病学杂志    2002 28 (1): 43-45   ISSN: 2096-5540  CN: 32-1880/R   念珠菌耐药机制在分子水平上的研究进展 王洪生, 骆志成, 武三卯 兰州医学院第二附属医院皮肤科 730030 收稿日期 2001-05-16  修回日期 null  网络版发布日期 null 参考文献  [1] Vanden Bossche H, Dromer F, Improvisi I, et al. Antifungal drug resistance in pathogenic fungi. Med Mycol, 1998,36 (Suppl 1): 119-128. [2] White TC, Marr KA, Bowden RA. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev,1998,11(2): 382-402. [3] Sanglard D, Ischer F, Calabrese D, et al. The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents. Antimicrob Agents Chemother,1999,43 (11): 2753-2765. [4] Krishnamurthy S, Gupta V, Prasad R, et al. Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones. FEMS Microbiol Lett,1998, 160(2): 191-197. [5] Franz R, Ruhnke M, Morschhauser J. Molecular aspects of fluconazole resistance development in Candida albicans. Mycoses, 1999,42(7-8): 453-458. [6] Miyazaki H, Miyazaki Y, Geber A, et al. Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene,PDH1, in Candida glabrata. Antimicrob Agents Chemother, 1998,42 (7):1695-1701. [7] Albertson GD, Niimi M, Cannon RD, et al. Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance. Antimicrob Agents Chemother, 1996, 40(12): 2835-2841. [8] Lyons CN, White TC. Transcriptional analyses of antifungal drug resistance in Candida albicans. Antimicrob Agents Chemother, 2000, 44(9):2296-2303. [9] Alarco AM, Raymond M. The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans.J Bacteriol, 1999,181(3): 700-708. [10] Sanglard D, Ischer F, Monod M,et al. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2,a new multidrug ABC transporter gene. Microbiology, 1997,143 (Pt 2):405-416. [11] Wirsching S, Michel S, Morschhauscr J. Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates. Mol Microbiol, 2000, 36(4): 856-865. [12] Gupta V, Kohli A, Krishnamurthy S, et al. Identification of polymorphic mntant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation. Curr Genet, 1998,34(3): 192-199. [13] Maesaki S, Marichal P, Hossain MA, et al. Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains.J Antimicrob Chemother, 1998, 42(6):747-753. [14] White TC. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans. Antimicrob Agents Chemother, 1997,41(7): 1488-1494. [15] Favre B, Didmon M, Ryder NS. Multiple amino acid substitutions in lanosterol 14alpha-demethylase contribute to azole resistance in Candida albicans. Microbiology, 1999,145 (Pt 10): 2715-2725. [16] Marichal P, Vanden Bossche H, Odds FC, et al. Molecular biological characterization of an azole-resistant Candida glabrata isolate. Antimicrob Agents Chemother, 1997,41(10): 2229-2237. [17] White TC. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemothe, 1997,41 (7): 1482-1487. [18] Asai K, Tsuchimori N, Okonpgi K, et al. Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. Antimicrob Agents Chemother, 1999,43(5): 1163-1169. [19] Goffeau A, Park J, Paulsen IT, et al. Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Yeast,1997,13(1): 43-54. [20] Perepnikhatka V, Fischer FJ, Niimi M, et al. Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans. J Bacteriol,1999,181(13): 4041-4049. 通讯作者: