国际皮肤性病学杂志    2001 27 (3): 147-149   ISSN: 2096-5540  CN: 32-1880/R   表皮生长因子受体及其配体与角质形成细胞 周小勇综述1, 郑家润审校2 1. 中国医学科学院皮肤病研究所; 2. 中国协和医科大学皮肤病研究所 收稿日期 null  修回日期 null  网络版发布日期 null 参考文献  [1] Shirakata Y,Komurasaki T,Toyoda H,et al.Epiregulin,a novel member of the epidermal growth factor family,is an autocrine growth factor in normal human keratinocytes.J Biol Chem,2000,275(8):5748-5753. [2] Pittelkow MR,Cook PW,Shipley GD,et al.Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy.Cell Growth Differ,1993,4(6):513-521. [3] Peus D,Hamacher L,Pittelkow MR,et al.EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation.J Invest Dermatol,1997,109(6):751-756. [4] Kobayashi T,Hashimoto K,Okumura HJ,et al.Endogenous EGF-family growth factors are necessary for the progression from the G1 to S phase in human keratinocytes.J Invest Dermatol,1999,111:616-620. [5] Cook PW,Piekorn M,Clegg CH,et al.Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.J Clin Invest,1997,100(9):2286-2294. [6] Rodeck U,Jost M,Kari C,et al.EGF-R dependent regulation of keratinocyte survival.J Cell Sci,1997,110(Pt 2):113-121. [7] Wakita H,Takigawa M.Activation of epidermal growth factor receptor promotes late terminal differentiation of cell-matrix interaction-disrupted keratinocytes.J Biol Chem,1999,274(52):37285-37291. [8] Wrone-Smith T,Mita RS,Thompson CB,et al.Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin.Am J Pathol,1997,151(5):1321-1329. [9] Jost M,Class R,Kari C,et al.A central role of Bcl-X(L) in the regulation of keratinocyte survival by autocrine EGFR ligands.J Invest Dermatol,1999,112(4):443-449. [10] Varani J,Kang S,Stoll S,et al.Human psoriatic skin in organ culture:comparison with normal skin exposed to exogenous growth factors and effectors of an antibody to the EGF receptor.Pathobiology,1998,66(6):253-259. [11] Powell TJ,Ben-Bassat H,Klein BY,et al.Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors.Br J Dermatol,1999,141(5):802-810. [12] Krane JF,Gottlieb AB,Carter DM,et al.The insulin-like growth factor Ⅰ receptor is overexpressed in psoriatic epidermis,but is differentially regulated from the epidermal growth factor receptor.J Exp Med,1992,175(4):1081-1090. [13] Nanney LB,Yates RA,King LE,et al.Modulation of epidermal growth factor receptors in psoriatic lesions during treatment with topical EGF.J Invest Dermatol,1992,98(3):296-301. [14] Valyi-Nagy I,Jensen PJ,Albelda SM,et al.Cytokine-induced expression of transforming growth factor-αand the epidermal growth factor receptor in neonatal skin explants.J Invest Dermatol,1992,99(3):350-356. [15] Gottlieb AB,Khandke L,Krane JF,et al.Anthralin decreases keratinocyte TGF-αexpression and EGF-receptor binding in vitro.J Invest Dermatol,1992,98(5):680-685. [16] Boisseau-Garsaud AM,Donatien P,Margerin C,et al.EGF receptor expression and growth of psoriatic and normal human keratinocytes are modulated by 1.25(OH)2-vitamin D3 ex vivo.Arch Dermatol Res,1996,288(8):453-457. [17] Krane JF,Murphy DP,Martin Carter D,et al.Synergistic effects of epidermal growth factor(EGF) and insulin-like growth factor Ⅰ/somatomedin C(IGF-Ⅰ) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor.JInvest Dermatol,1991,96(4):419-424. [18] Vardy DA,Kari C,Lazarus GS,et al.Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor.J Cell Physiol,1995,163(2):257-265. [19] Stoll S,Garner W,Elder J,et al.Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation in skin organ culture.J Clin Invest,1997,100(5):1271-1281. [20] Marques MM,Martinez N,Rodriguez-Garcia I,et al.EGFRfamily-mediated signal transduction in the human keratinocyte cell line HaCaT.Exp Cell Res,1999,252(2):432-438. [21] Choi JH,O'Connor TP,Kang S,et al.Activation of ribosomal protein S6 kinase in psoriatic lesions and cultured human keratinocytes by epidermal growth factor receptor ligands.J Invest Dermatol,1997,108(1):98-102. 通讯作者: