国际皮肤性病学杂志    2001 27 (1): 24-26   ISSN: 2096-5540  CN: 32-1880/R   白介素-1与痤疮 鞠强综述1, 石继海综述1, 夏隆庆审校2 1. 中国医学科学院皮肤病研究所; 2. 中国协和医科大学皮肤病研究所 收稿日期 null  修回日期 null  网络版发布日期 null 参考文献  [1] Cunliffe WJ.The sebaceous gland and acne-40 years on.Dermatology,1998,196(1):9-15. [2] Anttila HS,Reitamo S,Saurat JH,et al.Interleukin 1 immunoreactivitv in sebaceous glands.Br J Dermatol,1992,127:585-588. [3] Kupper TS,Groves RW.The interleukin-1 axis and cutaneous inflammation.J Invest Dermatol,1995,105(Suppl 1):S62-S66. [4] Dinarello CA.Biologic basis for interleukin-1 in disease.Blood,1996,87(6):2095-2147. [5] Ingham E,Eady EA,Goodwin CE,et al.Pro-inflammatory levels of intedeukin-lα-like bioactivity are present in the majority of open comedones in acne vulgaris.J Invest Dermatol,1992,98(6):895-901. [6] Eady EA,Ingham E,Walters CE,et al.Modulation of comedonal levels ofinterleukin-1 in acne patients treated with tetracyclines.J Invest Dermatol,1993,101(1):86-91. [7] Homemann S,Seltmann H,Kodelia V,et al.Interleukin lα mRNA and protein are expressed in cultured human sebocytes at steady-state and their levels are barely influenced by lipopolysac charides.J Invest Dermatol,1997,108:382. [8] Guy R,Green MR,Kealey T.Modeling acne in vitro.J Invest Dermatol,1996,106:176-182. [9] Groves RW,Rauschmayr T,Nakamura K,et al.Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor(tvpe 1)on epidermal keratinocytes.Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease.J Clin Invest,1996,98(2):336-344. [10] Kozlowska U,Blume-Peytavi U,Kodelja V,et al.Vascular endothelial growth factor expression induced by proinflammatory cytolines(interleukin 1α,β)in cells of the htman pilosebaceous unit.Dermatology,1998,196:89-92. [11] Guy R,Kealey T.Modelling the infundibulum in acne.Dermatology,1998,196:32-37. [12] Middleton MH,Norris DA.Cvtokine-induced ICAM-1 expression in human keratinocytes is highly variable in keratinocyte strains from different donors.J Invest Dermatol,1995,104(4):489-496. [13] Eller MC,Yaar M,Ostrom K,et al.A role for interleukin-1 in epidermal differentiation:regulation by expression of functional versus decoy receptors.J Cell Sci,1995,108(Pt 8):2741-2746. [14] Holland KT,Aldana Q,Bojar RA,et al.Propionibacterium acnes and acne.Dermatology,1998,196(1):67-68. [15] Ingham E,Walters CE,Eady EA,et al.Inflammation in acne vulgaris:failure of skin micro-organisms to modulate keratinocyte interleukin-1α production in vitro.Dermatology,1998,196:86-88. [16] Walters CE,Ingham E,Eady EA,et al.In vitro modulation of keratinocyte-derived interleukin-1α(IL-1α)and peripheral blood mononuclear cell-derived IL-1β release in response to cutaneous commensal microorganisms.Infect Immun,1995,63:1223-1228. [17] Bohm M,Luger TA.The pilosebaceous unit is part of the skin immune system.Dermatology,1998,196(1):75-79. [18] Zouboulis CC,Xia L,Akamatsu H,et al.The human sebocyte culture model provides new insights into development and management of seborrhoea and acne.Dermatology,1998,196:21-31. 通讯作者: