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Phaeohyphomycosis is an entity caused by local infection in superficial tissue, skin, cornea, subcutaneous tissue and even systemic infection with a large group of dematiaceous fungi. It is important to promptly diagnose and exactly manage this disorder, otherwise, fatal disseminated phaeohyphomycosis may occur. Phaeohyphomycosis is mainly managed with surgical excision, with or without antifungal therapy. A number of antifungals, for example, amphotericin B, itraconazole and posaconazole prove to be effective for the treatment of this infection. This article describes the present status of phaeohyphomycosis treatment, which may provide a reference to clinicians.