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Androgenic alopecia (AGA) is the most common type of hair loss. Its pathogenesis remains unclear. Now AGA is defined as an androgen-dependent disease with characteristic multifactorial inheritance. Androgen receptor gene located on the X chromosome was first found as a susceptibility gene of AGA. Further more, the sex-determining gene located on the Y chromosome and the hairless gene on the autosome gene were also associated with AGA. Recently, scholars have revealed another two susceptibility loci on chromosome 3 q 26 and 20 p11 using genome-wide scan and fine-mapping linkage methods, which may provide further clues to the research of genetic mechanism of AGA.