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Epigenetic studies have indicated the importance of DNA hypomethylation in the etiology of systemic lupus erythematosus ��SLE��. DNA methyltransferases is the catalyst of DNA methylation reaction, as well as an important molecule interfering the methylation level. The mRNA transcriptional level and activity of DNA methyltransferases are regulated by various factors, such as promoter epitope modification, signal transducer and activator of transcription-3 ��STAT3��, transcription factor Sp1 and Sp3, tumor-suppressing gene p53, methyl-CpG binding proteins ��MeCP2��, and so on. The expression and activity of DNA methyltransferases are downregulated in patients with lupus erythematous, which is linked with the DNA hypomethylation of T cells. To investigate the action pathway of DNA methyltransferases in the epigenetic pathogenesis of systemic lupus erythematosus, and to disclose the regulation mechanism of epigenetic inheritance of systemic lupus erythematosus, may provide new strategies and regimens for the treatment of this disease.