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����Ů��29�ꡣ�����沿�����������Ժ��26�꣬�֡���ؽڱ���14�ꡣƤ��ÿ�շ������麮ս�����ȡ��ۺ졢�ؽ�ʹ����죺��İ�С���������⣬�����ǣ��͹������˫�۽�Ĥ��Ѫ���沿�����������Ժ�ߣ��֡���ؽڱ��Ρ��沿�����̼���Ƥ����سʵ��ͷ��š����ݵ���֢״���ΪCryopyrin��������������ۺ�����

A 29-year-old woman was referred to the hospital due to recurrent generalized erythema on the face and trunk for 26 years and joint deformity in the hands and feet for 14 years. The nonpruritic rash occurred every day with low-grade fever, chill, eye redness and arthralgia. Physical examination revealed growth retardation, characteristic facial appearance with a saddle back nose and frontal bossing, conjunctival congestion of both eyes, diffused erythema on the face and trunk and joint deformity. After her face was exposed to artificial cold wind, the rash worsened and turned into typical wheals. According to the typical clinical manifestation, this case was diagnosed as cryopyrin associated periodic syndromes.