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Vitiligo is associated with the function loss of epidermal melanocytes. Cytokines can affect the biological characters of melanocytes through autocrine or paracrine modes of action. Several kinds of cytokines and their receptors on melanocytes play important roles in the growth, differentiation, proliferation, apoptosis, production and transport of melanin, of melanocytes. It has been demonstrated that the growth, differentiation and proliferation of melanocytes can be promoted by melanocyte-stimulating hormone, granulocyte-macrophage colony stimulating factor, stem cell factor, basic fibroblast growth factor, etc, whereas tumor necrosis factor α and interleukin have an inhibitory effect on the growth of melanocytes.