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Melanoma is a highly invasive tumor with a high capacity for both lymphatic and hematogeneous metastasis formation. The invasion and metastasis of melanoma are a complicated process, and involve many molecules, including intercellular adhesion molecules, extracellular matrix��chemotactic factors, angiogenic and lymphangiogenic factors, etc. A thorough insight into the molecular mechanism would provide new ideas for the diagnosis and treatment of melanoma.