�����人���пƼ���ѧͬ��ҽѧԺ����Э��ҽԺ

��֬������3-��ø�źŲ�����ֳ���ֻ���������������ת�˵ȶ���ϸ�����ܵĵ��ڡ����������֣���A����֬������3-��ø�������η��ӵ��׼�øB����ɵ��ź�ͨ·��������Ժ������ķ�����չ������ء���ͨ·���ں�����ϸ������ֳ�ʹ�������쳣����������ϸ������ת���������������ϸ����Ǩ�ơ�𤸽��Ѫ�������Լ�ϸ������ʵĽ������ء�Ŀǰ����֬������3-��ø-Akt�ź�ͨ·�ؼ�����Ϊ�е�Ķ��Ժ��������Ʋ��������о��С�

Phosphatidylinositol-3-kinase ��PI3K�� signaling pathway participates in the regulation of many kinds of cell biological behavior, e.g., proliferation, differentiation, apoptosis and transport of glucose. Recently, it has been revealed that the signaling pathway consisting class Ia PI3K and its downstream molecule protein kinase B��PKB/Akt�� has a close relationship with the occurrence and development of human malignant melanoma. The pathway can regulate the proliferation and survival of melanoma cells. The abnormality of this pathway can not only cause malignant transformation but also affect the migration, adherence, angiogenesis and extracellular matrix degradation of melanoma cells. Currently, therapeutic strategy targeting the key molecules in PI3K pathway is under research of malignant melanoma.