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osinophils are associated with many dermatoses. In atopic dermatitis��AD�� and hypereosinophilic syndrome ��HES��, T helper 2 cytokines including interleukin 5 can induce the increase of eosinophil count, enhance cell chemotaxis and activation, and delay cell apoptosis. A fusion gene is reported to be responsible for the hypereosinophilia in myeloproliferative subtype of HES. The infiltration of eosinophils into tissue is the interactive effect of a series of adhesion molecules, chemokines and cytokines. Eosinophils exert inflammation-modulating and cytotoxic effects by releasing granule proteins, lipid bodies and cytokines.