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Nuclear factor��NF��-kappa B signaling pathway not only takes part in cell growth, differentiation and inflammation reactions by regulating the expression of related genes, but also participates in the genesis, progression and metastasis of tumors. Recent studies have indicated that NF-kappa B signaling pathway��as a molecular switch from pro-apoptotic to anti-apoptotic melanoma, is involved in the growth, proliferation, differentiation, apoptosis of melanoma cells as well as the invasion and metastasis of melanoma. It may be of some importance for the treatment and prevention of melanoma to search cell-specific immunoregulatory agents to precisely modulate the activity of NF-kappa B.