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Psoriasis is an autoimmune disease that is associated with T lymphocytes. Recent research has shown that besides Th1 cells, Th17 cells and related cytokines play a very important role in the pathogenesis of psoriasis. The differentiation and activation of T lymphocytes requires the participation of antigen-presenting cells. Cytokines released by activated mast cells also take part in the pathogenesis of psoriasis. Therefore, a great many of immunocytes and cytokines are involved in the development of psoriasis. To elucidate the immunologic mechanism in the pathogenesis of psoriasis may provide theoretic evidence for the development of new approaches to psoriasis treatment.