����ҽѧԺ�ڶ�����ҽԺ ����ҽѧԺ�ڶ�����ҽԺ

ϸ������T�ܰ�ϸ����ؿ�ԭ-4�ɱ��������ϸ��Ϊ���Ķ���ϸ����ϸ������T��ϸ����ؿ�ԭ-4 Ig�Ϳ�������ϸ������T��ϸ����ؿ�ԭ-4���ڷ������������Լ�������ֲ�ų⼰���������ַ��ӣ���Ч���ڶ���ʵ�鼰�ٴ�Ӧ�����ѵõ�֤ʵ��SLE��һ�ֳ������ۼ����������������Լ�����������ѧ������Tϸ����Ӧ�����Bϸ�����Ե����ϰ����Ӷ�����Bϸ���߻��ԺͲ������������塣

Cytotoxic T lymphocyte-associated molecule-4 ��CTLA-4��, a member of B7/CD28 family, is expressed mainly by immune cells. It has multiple immunologic effects and plays a central role in down-regulating immune responses. Animal experiments and clinical practices have confirmed the efficacy of CTLA-4 immunoglobulin and anti-CTLA-4 monoclonal antibody in the prevention and treatment of autoimmune diseases, transplantation rejection and tumors. Systemic lupus erythematosus ��SLE��, a common autoimmune disease involving multiple organs, is immunologically characterized by dysfunction of T cells and dysregulation of B-cell activity, which leads to an increase in the activity of and autoantibody production by B cells.