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Estrogens have a profound influence on skin. Relative hypoestrogenism is proved to accelerate the intrinsic and environmental aging of skin. Certain quantity of estrogens can cause an increase in skin thickness, hydration, elasticity and a reduction in skin wrinkling. So, estrogens are effective for the treatment of skin aging. The efficacy and safety of topical estrogens have been confirmed, however, additional evidence is needed to support the beneficial effect of hormone replacement therapy ��HRT�� on skin aging.