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Itch is the commonest symptom in skin diseases. However, the mechanism of itch is not identified clearly. It is thought that there's an independent neural pathway through which itch is transferred mainly by peripheral unmyelinated C fibers to the most superficial part of dorsal horn, then the lamina �� spinothalamic tract ascends to the thalami and further projects to the cortex. Itch derived from skin is closely associated with many itch mediators. Besides histamine, other mediators such as acetylcholine, proteases, substance P, prostaglandin, cytokines and their receptors are involved in the mechanism of itch. This review introduces the clinical classification, neural pathway and itch mediators of skin-derived itch.