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As an important signal transducer and intercellular adhesion molecular, β-catenin has turned into a hotspot in recent studies on proteins. β-catenin is a key protein for modulation of Wnt signaling pathway and an important intracellular component of E-cd/cat complex involved in intercellular adhesion and link. It also participate in many biologic behaviors including tumorigenesis, proliferation, differentiation, invasion and metastasis of tumors. To detect the level of membranous β-catenin and aberrant��nuclear/cytoplasmic) localization of β-catenin may be of some significance to understand the biological features, types and prognosis of tumors. Meanwhile, blocking the abnormal activation of β-catenin signaling pathway is expected to be a new approach to the treatment of tumors.