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Ŀ�� ̽��5-����ͪ���ᣨALA���յ���ӫ����Ϸ�����ϼ���ʪ�ࣨCA�����ٴ���Ⱦ�еļ�ֵ������ �ٴ����ѡ��25��CA���ߣ��������弰��Χ5 cm��Χ��������20�� ALA��ಢ�������2 h��4 hʱ��410 nm����۲���ҩ��λ��������������ͬ��λ���д�������飬�۲�������� 25�������У�����ALA������Ϊ100�������������������Ϊ80����������ΧALA������Ϊ96�������������������Ϊ8�������ʵļ��ʱ��Ϊ��ҩ��2 h�����Ĥ����֢��λ�Դ���һ���ļ����ԡ����� ALA��CA�����弰����Χ���ٴ���Ⱦ����������ڴ�ͳ�Ĵ�������飬��CA����Ϻͼ�������о���һ����ֵ��

Objective To evaluate the performance of 5-aminolevulinic acid (ALA)-mediated photodynamic diagnosis in subclinical lesions of condylomata acuminatum . Methods Twenty-five patients with condylomata acuminanta were recruited into this study. ALA 20% cream was applied under occlusive dressings in clinical lesions and subclinical lesions ( 5cm around the lesions) of the patients. Fluorescence was observed by 410 nm light 2 and 4 hours after the application of ALA. Acetowhitening test was also performed in the same skin areas. Results Among the 25 patients, ALA test was positive in 100% and 96% of clinical lesions and subclinical lesions respectively, while acetowhitening test was in only 80% and 8% of these lesions respectively; the difference was significant between the two tests in the positivity rates in clinical and subclinical lesions. The optimal time for diagnosis was in 2 hours after the application of ALA. False positive reaction was noted in mucosal and inflammatory tissue. Conclusions ALA test is superior to acetowhitening test in the diagnosis of clinical and subclinical lesions of condylomata acuminatum. So, it is promising for the diagnosis and differential diagnosis of condylomata acuminatum.